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Recombinant Mouse Bap1; Protein, MYC/DDK-tagged

Cat.No. : Bap1-259M
Product Overview : Purified recombinant protein of full-length mouse Brca1 associated protein 1 (Bap1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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  • Gene Information
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Description : Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration. Acts as a tumor suppressor.
Source : HEK293T
Species : Mouse
Tag : MYC/DDK
Molecular Mass : 80.5 kDa
Purity : >80%, as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 ug/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Bap1 Brca1 associated protein 1 [ Mus musculus (house mouse) ]
Official Symbol : Bap1;
Synonyms : Bap1 Brca1 associated protein 1 [ Mus musculus (house mouse) ]
Gene ID : 104416
mRNA Refseq : NM_027088
Protein Refseq : NP_081364
UniProt ID : Q99PU7

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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