Recombinant Mouse Bmp3 Protein, MYC/DDK-tagged Bmp3-450M

Recombinant Mouse Bmp3 Protein, MYC/DDK-tagged


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Recombinant Mouse Bmp3 Protein, MYC/DDK-tagged

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Cat.No. : Bmp3-450M
Product Overview : Purified recombinant protein of full-length mouse bone morphogenetic protein 3 (Bmp3), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
Description : This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein suppresses osteoblast differentiation, and negatively regulates bone density, by modulating TGF-beta receptor availability to other ligands. Homozygous knockout mice for this gene exhibit increased bone density and volume, while overexpression of this gene in a transgenic mouse causes bone defects resulting in spontaneous rib fractures. This gene encodes distinct protein isoforms that may be similarly proteolytically processed.
Source : HEK293T
Species : Mouse
Molecular Mass : 52.8 kDa
Purity : >80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Bmp3 bone morphogenetic protein 3 [ Mus musculus (house mouse) ]
Official Symbol : Bmp3
Synonyms : Bmp3; bone morphogenetic protein 3; 9530029I04Rik; bone morphogenetic protein 3;
Gene ID : 110075
mRNA Refseq : NM_173404
Protein Refseq : NP_775580
UniProt ID : Q8BHE5

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