Recombinant Mouse Bmp3 Protein, MYC/DDK-tagged

• Cat.No.: Bmp3-450M
• Product Overview: Purified recombinant protein of full-length mouse bone morphogenetic protein 3 (Bmp3), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein suppresses osteoblast differentiation, and negatively regulates bone density, by modulating TGF-beta receptor availability to other ligands. Homozygous knockout mice for this gene exhibit increased bone density and volume, while overexpression of this gene in a transgenic mouse causes bone defects resulting in spontaneous rib fractures. This gene encodes distinct protein isoforms that may be similarly proteolytically processed.
• Source: HEK293T
• Species: Mouse
• Tag: MYC/DDK
• Molecular Mass: 52.8 kDa
• Purity: >80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Bmp3 bone morphogenetic protein 3 [ Mus musculus (house mouse) ]
• Official Symbol: Bmp3
• Synonyms: Bmp3; bone morphogenetic protein 3; 9530029I04Rik; bone morphogenetic protein 3
• Gene ID: 110075
• mRNA Refseq: NM_173404
• Protein Refseq: NP_775580
• UniProt ID: Q8BHE5