Recombinant Mouse Brd8 Protein, Myc/DDK-tagged Brd8-1891M

Recombinant Mouse Brd8 Protein, Myc/DDK-tagged

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Cat.No. : Brd8-1891M Optional Service: Optional requirements on this protein
Product Overview : Purified recombinant protein of mouse full-length bromodomain containing 8 (cDNA clone MGC:36597 IMAGE:5323755), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells.
Description : May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 99.3 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Brd8 bromodomain containing 8 [ Mus musculus (house mouse) ]
Official Symbol : Brd8
Synonyms : Brd8; bromodomain containing 8; S; p12; SMAP; 2610007E11Rik; 4432404P07Rik; bromodomain-containing protein 8
Gene ID : 78656
mRNA Refseq : NM_030147
Protein Refseq : NP_084423
UniProt ID : Q8R3B7
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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