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Recombinant Mouse Cd28 Protein, His-tagged, Alexa Fluor 555 conjugated

Cat.No. : Cd28-4008MAF555
Product Overview : Alexa Fluor 555 conjugated recombinant Mouse Cd28 (Asn20-Lys149) protein was fused to His-tag at C-terminus and expressed in human 293 cells (HEK293).
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Description : T-cell-specific surface glycoprotein CD28 is also known as TP44, is a single-pass type I membrane protein which contains one Ig-like V-type (immunoglobulin-like) domain. is one of the molecules expressed on T cells that provide co-stimulatory signals, which are required for T cell activation. CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2). When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells.
Source : HEK293
Species : Mouse
Tag : His
Form : Lyophilized
Molecular Mass : The protein has a calculated MW of 16.9 kDa. The protein migrates as 30-35 kDa and 55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Protein length : Asn20-Lys149
N-terminal Sequence Analysis : Asn 20
Endotoxin : < 1.0 EU/ μg by the LAL method.
Purity : > 90 % as determined by SDS-PAGE
Characteristic : Disulfide-linked homodimer
Labeled with Alexa Fluor 555 via amines
With an excitation and emission maximum of 555/565 nm, Alexa Fluor 555 can be efficiently excited using a 543 nm He-Ne laser line and detected under standard TRITC/Cy3 filters.
Storage : For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
Storage Buffer : Lyophilized from 0.22 μm filtered solution in PBS, pH7.4, 10% trehalose.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 μg/μL. Centrifuge the vial at 4 centigrade before opening to recover the entire contents.
Gene Name : Cd28
Official Symbol : Cd28
Synonyms : CD28; CD28 antigen; T-cell-specific surface glycoprotein CD28
Gene ID : 12487
mRNA Refseq : NM_007642
Protein Refseq : NP_031668
UniProt ID : P31041

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can CD28 protein be used for personalized medicine? 01/13/2023

CD28 protein expression and function may be relevant for personalized treatment strategies in autoimmune diseases and cancer.

What are the potential clinical applications of targeting CD28 protein? 05/18/2021

Targeting CD28 protein may have therapeutic potential in treating autoimmune diseases, cancer immunotherapy, and organ transplantation.

How does CD28 protein impact regulatory T cells (Tregs)? 06/21/2019

CD28 signaling is important for the function and maintenance of regulatory T cells, which play a role in immune tolerance and suppression of autoimmunity.

How does CD28 protein impact cancer immunotherapy? 11/26/2018

CD28 protein is involved in enhancing the anti-tumor immune response, making it a potential target for cancer immunotherapy.

Are there any approved therapies targeting CD28 protein? 05/27/2017

Currently, there are no FDA-approved therapies specifically targeting CD28 protein, but research is ongoing in this area.

Customer Reviews (3)

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08/24/2021

    Its unique characteristics contribute to obtaining clear and detailed structural information, enabling researchers to unravel the intricate complexities of protein interactions and conformational changes.

    08/24/2021

      Researchers can confidently rely on its capabilities to generate precise and significant results, enhancing the understanding of protein function and dynamics.

      08/06/2021

        the CD28 protein's outstanding performance in ELISA and its utility in protein electron microscopy structure analysis make it a highly recommended tool for researchers.

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