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Recombinant Mouse Cdk8 Protein, Myc/DDK-tagged

Cat.No. : Cdk8-2091M
Product Overview : Purified recombinant protein of mouse full-length cyclin-dependent kinase 8 (Cdk8), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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Description : Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 53.7 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Cdk8 cyclin-dependent kinase 8 [ Mus musculus (house mouse) ]
Official Symbol : Cdk8
Synonyms : CDK8; cyclin-dependent kinase 8; mediator complex subunit CDK8; cell division protein kinase 8; mediator of RNA polymerase II transcription subunit CDK8; MGC37111
Gene ID : 264064
mRNA Refseq : NM_153599
Protein Refseq : NP_705827
UniProt ID : Q8R3L8

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Is CDK8 exclusively associated with cancer, or does it have physiological roles in normal cellular functions? 01/31/2020

CDK8 plays essential roles in normal cellular functions, including development and tissue homeostasis. Its dysregulation, however, is implicated in cancer.

Can CDK8 inhibitors be used in combination with other cancer treatments, and if so, what are the potential benefits? 11/07/2019

Combination therapies involving CDK8 inhibitors are being explored to enhance treatment outcomes and reduce the likelihood of resistance, providing a more comprehensive approach to cancer management.

How does CDK8 inhibition affect the cell cycle, and why is this significant in cancer therapy? 12/30/2018

CDK8 inhibition can disrupt the cell cycle, slowing down or halting the uncontrolled cell division characteristic of cancer cells, making it a potential therapeutic strategy.

How does CDK8 influence the immune response in the tumor microenvironment? 07/21/2017

CDK8 can modulate the expression of genes involved in immune response. Understanding its role in the tumor microenvironment may lead to novel immunotherapeutic strategies.

Are there ongoing clinical trials investigating the efficacy of CDK8 inhibitors in cancer patients? 06/11/2016

Yes, several clinical trials are underway to assess the safety and effectiveness of CDK8 inhibitors as a targeted therapy for different types of cancer.

Customer Reviews (3)

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Reviews
03/05/2020

    The CDK8 protein stands as a remarkable solution that exemplifies exceptional quality and meets all my experimental requirements.

    08/03/2019

      I am confident that the CDK8 protein will unlock vital insights into cellular processes, propelling my scientific investigations to new heights.

      10/01/2017

        Its impressive purity and functional characteristics make it an ideal choice for my research endeavors, ensuring reliable and impactful results.

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