Recombinant Mouse Cdk8 Protein, Myc/DDK-tagged
Cat.No. : | Cdk8-2091M |
Product Overview : | Purified recombinant protein of mouse full-length cyclin-dependent kinase 8 (Cdk8), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
- Specification
- Gene Information
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Description : | Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 53.7 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Cdk8 cyclin-dependent kinase 8 [ Mus musculus (house mouse) ] |
Official Symbol : | Cdk8 |
Synonyms : | CDK8; cyclin-dependent kinase 8; mediator complex subunit CDK8; cell division protein kinase 8; mediator of RNA polymerase II transcription subunit CDK8; MGC37111 |
Gene ID : | 264064 |
mRNA Refseq : | NM_153599 |
Protein Refseq : | NP_705827 |
UniProt ID : | Q8R3L8 |
Products Types
◆ Recombinant Protein | ||
CDK8-1039H | Active Recombinant Human CDK8 Protein, His-Tagged | +Inquiry |
CDK8-1038H | Active Recombinant Human CDK8 Protein, GST-Tagged | +Inquiry |
CDK8-616R | Recombinant Rhesus Macaque CDK8 Protein, His (Fc)-Avi-tagged | +Inquiry |
CDK8-1531M | Recombinant Mouse CDK8 Protein, His (Fc)-Avi-tagged | +Inquiry |
CDK8-10H | Recombinant Human CDK8, MYC/DDK-tagged | +Inquiry |
◆ Lysates | ||
CDK8-7620HCL | Recombinant Human CDK8 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionCDK8 plays essential roles in normal cellular functions, including development and tissue homeostasis. Its dysregulation, however, is implicated in cancer.
Combination therapies involving CDK8 inhibitors are being explored to enhance treatment outcomes and reduce the likelihood of resistance, providing a more comprehensive approach to cancer management.
CDK8 inhibition can disrupt the cell cycle, slowing down or halting the uncontrolled cell division characteristic of cancer cells, making it a potential therapeutic strategy.
CDK8 can modulate the expression of genes involved in immune response. Understanding its role in the tumor microenvironment may lead to novel immunotherapeutic strategies.
Yes, several clinical trials are underway to assess the safety and effectiveness of CDK8 inhibitors as a targeted therapy for different types of cancer.
Customer Reviews (3)
Write a reviewThe CDK8 protein stands as a remarkable solution that exemplifies exceptional quality and meets all my experimental requirements.
I am confident that the CDK8 protein will unlock vital insights into cellular processes, propelling my scientific investigations to new heights.
Its impressive purity and functional characteristics make it an ideal choice for my research endeavors, ensuring reliable and impactful results.
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