Recombinant Mouse Cldn2 Protein, MYC/DDK-tagged

• Cat.No.: Cldn2-900M
• Product Overview: Purified recombinant protein of full-length mouse claudin 2 (Cldn2), with C-terminal MYC/DDK tag, was expressed in HEK293T cells.

Specification

• Description: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The knockout mice lacking this gene display normal appearance, activity, growth and behavior, but are defective in the leaky and cation-selective paracellular permeability properties of renal proximal tubules. The proteins encoded by this gene and another family member Cldn12 are also critical for vitamin D-dependent Ca2+ absorption between enterocytes.
• Source: HEK293T
• Species: Mouse
• Tag: MYC/DDK
• Molecular Mass: 24.5 kDa
• Purity: >80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 µg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Cldn2 claudin 2 [ Mus musculus (house mouse) ]
• Official Symbol: Cldn2
• Synonyms: Cldn2; claudin 2; AL022813; claudin-2
• Gene ID: 12738
• mRNA Refseq: NM_016675
• Protein Refseq: NP_057884
• UniProt ID: O88552