Recombinant Mouse Cmtm4 Protein, Myc/DDK-tagged

• Cat.No.: Cmtm4-2211M
• Product Overview: Purified recombinant protein of mouse full-length CKLF-like MARVEL transmembrane domain containing 4 (Cmtm4), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Acts as a backup for CMTM6 to regulate plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. May protect PD-L1/CD274 from being polyubiquitinated and targeted for degradation.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 22.9 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Cmtm4 CKLF-like MARVEL transmembrane domain containing 4 [ Mus musculus (house mouse) ]
• Official Symbol: Cmtm4
• Synonyms: CMTM4; CKLF-like MARVEL transmembrane domain containing 4; CKLF-like MARVEL transmembrane domain-containing protein 4; chemokine-like factor super family 4; chemokine-like factor superfamily member 4; D19397; Gm9853; Cklfsf4; MGC30490; MGC32180; ENSMUSG00000051554
• Gene ID: 97487
• mRNA Refseq: NM_153582
• Protein Refseq: NP_705810
• UniProt ID: Q8CJ61