Recombinant Mouse Cyrib Protein, Myc/DDK-tagged

• Cat.No.: Cyrib-2942M
• Product Overview: Purified recombinant protein of mouse full-length family with sequence similarity 49, member B (Fam49b), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Negatively regulates RAC1 signaling and RAC1-driven cytoskeletal remodeling. Regulates chemotaxis, cell migration and epithelial polarization by controlling the polarity, plasticity, duration and extent of protrusions. Limits Rac1 mediated activation of the Scar/WAVE complex, focuses protrusion signals and regulates pseudopod complexity by inhibiting Scar/WAVE-induced actin polymerization. Protects against Salmonella bacterial infection. Attenuates processes such as macropinocytosis, phagocytosis and cell migration and restrict sopE-mediated bacterial entry. Restricts also infection mediated by Mycobacterium tuberculosis and Listeria monocytogenes. Involved in the regulation of mitochondrial dynamics and oxidative stress.
• Molecular Mass: 36.8 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Cyrib CYFIP related Rac1 interactor B [ Mus musculus (house mouse) ]
• Official Symbol: Cyrib
• Synonyms: Cyrib; CYFIP related Rac1 interactor B; Fam49; Fam49b; AW122079; 0910001A06Rik; CYFIP-related Rac1 interactor B; family with sequence similarity 49, member B; protein FAM49B
• Gene ID: 223601
• mRNA Refseq: NM_144846
• Protein Refseq: NP_659095
• UniProt ID: Q921M7