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Recombinant Mouse Dck Protein, Myc/DDK-tagged

Cat.No. : Dck-2472M
Product Overview : Purified recombinant protein of mouse full-length deoxycytidine kinase (Dck), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
  • Specification
  • Gene Information
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Description : Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA).
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 30.4 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Dck deoxycytidine kinase [ Mus musculus (house mouse) ]
Official Symbol : Dck
Synonyms : DCK; deoxycytidine kinase
Gene ID : 13178
mRNA Refseq : NM_007832
Protein Refseq : NP_031858
UniProt ID : P43346

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How is DCK implicated in resistance to chemotherapy? 09/01/2022

Reduced DCK activity or expression can lead to resistance against nucleoside analog-based chemotherapy.

What therapeutic strategies are being explored to modulate DCK activity? 07/10/2021

Strategies include modulating DCK levels to overcome drug resistance and improve treatment outcomes.

What is the significance of DCK in the action of certain chemotherapeutic agents? 04/28/2021

DCK activation of prodrugs enhances their cytotoxicity, improving chemotherapeutic efficacy.

Are there known genetic variants of DCK associated with different responses to treatment? 09/14/2020

Genetic variants in DCK have been linked to varied responses to nucleoside analog drugs.

How does DCK contribute to nucleoside metabolism? 08/27/2018

It phosphorylates deoxyribonucleosides, contributing to their conversion to active triphosphate forms.

In which types of cells or tissues is DCK predominantly expressed? 06/17/2018

DCK is widely expressed but shows higher activity in proliferating cells and certain tissues like the liver.

What is the primary role of DCK in cellular processes? 02/22/2018

DCK plays a crucial role in activating nucleoside analog prodrugs.

Customer Reviews (3)

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Reviews
08/05/2020

    Worked as expected, pure.

    07/01/2020

      Excellent for research, quality.

      07/26/2018

        Fast shipping, reliable product.

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