Recombinant Mouse Dmrt1 Protein, Myc/DDK-tagged
Cat.No. : | Dmrt1-2587M |
Product Overview : | Purified recombinant protein of mouse full-length doublesex and mab-3 related transcription factor 1 (Dmrt1), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
- Specification
- Gene Information
- Related Products
Description : | Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 39.9 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Dmrt1 doublesex and mab-3 related transcription factor 1 [ Mus musculus (house mouse) ] |
Official Symbol : | Dmrt1 |
Synonyms : | DMRT1; doublesex and mab-3 related transcription factor 1; doublesex- and mab-3-related transcription factor 1 |
Gene ID : | 50796 |
mRNA Refseq : | NM_015826 |
Protein Refseq : | NP_056641 |
UniProt ID : | Q9QZ59 |
Products Types
◆ Recombinant Protein | ||
DMRT1-2709H | Recombinant Human DMRT1 Protein, GST-tagged | +Inquiry |
DMRT1-2414M | Recombinant Mouse DMRT1 Protein, His (Fc)-Avi-tagged | +Inquiry |
DMRT1-11775Z | Recombinant Zebrafish DMRT1 | +Inquiry |
DMRT1-3742C | Recombinant Chicken DMRT1 | +Inquiry |
DMRT1-27093TH | Recombinant Human DMRT1 | +Inquiry |
◆ Lysates | ||
DMRT1-6898HCL | Recombinant Human DMRT1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket