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Recombinant Mouse Dnajb12 Protein, Myc/DDK-tagged

Cat.No. : Dnajb12-2596M
Product Overview : Purified recombinant protein of mouse full-length DnaJ heat shock protein family (Hsp40) member B12 (Dnajb12), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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Description : Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway. Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities. Can also act independently of HSPA8/Hsc70: together with DNAJB14, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers. While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70. When overexpressed, forms membranous structures together with DNAJB14 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 42 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Dnajb12 DnaJ heat shock protein family (Hsp40) member B12 [ Mus musculus (house mouse) ]
Official Symbol : Dnajb12
Synonyms : Dnajb12; DnaJ heat shock protein family (Hsp40) member B12; Dj10; mDj10; dnaJ homolog subfamily B member 12; DnaJ (Hsp40) homolog, subfamily B, member 12; DnaJ homolog 10
Gene ID : 56709
mRNA Refseq : NM_019965
Protein Refseq : NP_064349
UniProt ID : Q9QYI4

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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