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Recombinant Mouse Fbln5 Protein, Myc/DDK-tagged

Cat.No. : Fbln5-2959M
Product Overview : Purified recombinant protein of mouse full-length fibulin 5 (Fbln5), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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Description : Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN. Stabilizes and organizes elastic fibers in the skin, lung and vasculature. Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling. May act as an adapter that mediates the interaction between FBN1 and ELN.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 50.2 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Fbln5 fibulin 5 [ Mus musculus (house mouse) ]
Official Symbol : Fbln5
Synonyms : FBLN5; fibulin 5; fibulin-5; FIBL-5; developmental arteries and neural crest EGF-like protein; A55; EVEC; DANCE
Gene ID : 23876
mRNA Refseq : NM_011812
Protein Refseq : NP_035942
UniProt ID : Q9WVH9

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Is there a relationship between the structure and function of FBLN5? 06/27/2023

The structure of FBLN5 determines its ability and stability to bind to other proteins. The study of its structure can help us understand its function and mechanism of action.

Does lack or overexpression of FBLN5 make a difference? 06/25/2022

FBLN5 deficiency may lead to uncontrolled fibrinogen activity, resulting in premature degradation of fibrin, affecting the process of blood coagulation and hemostasis. However, the overexpression of FBLN5 may over-inhibit the activity of plasminogen, resulting in abnormal blood coagulation and hemostasis.

What is the main function of FBLN5 in the blood? 06/15/2022

The main function of FBLN5 in the blood is to bind and regulate the action of fibrinogen, prevent excessive degradation of fibrin in the blood, maintain blood flow and normal clotting process.

What are the therapeutic strategies for FBLN5? 12/26/2021

Therapeutic strategies for FBLN5 may include supplementing or inhibiting its expression and regulating its interaction with other proteins. These methods may have potential application value in the treatment of coagulation disorders and thrombosis.

Does FBLN5 interact with other proteins? 12/25/2021

It can interact with a variety of other proteins, including fibrinogen and plasminogen. These interactions allow it to regulate the metabolism of fibrin and the blood clotting process.

Does FBLN5 play a role in cardiovascular disease? 01/20/2021

In cardiovascular disease, FBLN5 may influence disease development and prognosis by regulating fibrin metabolism and coagulation processes. It could be a potential target for the treatment of cardiovascular disease.

Customer Reviews (3)

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Reviews
07/11/2023

    FBLN5 has good stability in different environments and is not easy to degrade.

    05/29/2023

      FBLN5 is accurately positioned in the bands in Western blot, showing good specificity.

      09/23/2020

        Good stability in vivo.

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