Recombinant Mouse Fbxl12 Protein, Myc/DDK-tagged

• Cat.No.: Fbxl12-2960M
• Product Overview: Purified recombinant protein of mouse full-length F-box and leucine-rich repeat protein 12 (Fbxl12), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 30.6 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Fbxl12 F-box and leucine-rich repeat protein 12 [ Mus musculus (house mouse) ]
• Official Symbol: Fbxl12
• Synonyms: FBXL12; F-box and leucine-rich repeat protein 12; F-box/LRR-repeat protein 12; F-box protein FBL12; F-box protein containing leucine repeats 12; Fbl12; 3110048D16Rik
• Gene ID: 30843
• mRNA Refseq: NM_001002846
• Protein Refseq: NP_001002846
• UniProt ID: Q9EPX5