Recombinant Mouse Fbxo2 Protein, Myc/DDK-tagged

• Cat.No.: Fbxo2-2964M
• Product Overview: Purified recombinant protein of mouse full-length F-box protein 2 (Fbxo2), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 33.7 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Fbxo2 F-box protein 2 [ Mus musculus (house mouse) ]
• Official Symbol: Fbxo2
• Synonyms: FBXO2; F-box protein 2; F-box only protein 2; prion protein ligand 4; FBG1; FBX2; Fbs1; Fbs2; NFB42; Prpl4; MGC54895
• Gene ID: 230904
• mRNA Refseq: NM_176848
• Protein Refseq: NP_789818
• UniProt ID: www.uniprot.org/uniprot/Q80UW2