Recombinant Mouse Fibroblast Growth Factor 21, FLAG-tagged
Cat.No. : | Fgf21-414M |
Product Overview : | Recombinant mouse fibroblast growth factor 21 (FGF-21) (aa 1-210) produced inHEK 293 cellsis fused at the C-terminus to a FLAG-tag. |
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Cat. No. : | Fgf21-414M |
Description : | FGF-21 is preferentially expressed in liver, but an exact knowledge of FGF-21 bioactivity and its mode of action have been lacking to date. FGF-21 is a potent activator of glucose uptake on adipocytes, protects animals from diet-induced obesity when overexpressed in transgenic mice, and lowers blood glucose and triglyceride levels when therapeutically administered to diabetic rodents. |
Source/Host : | HEK 293 cells. |
Purity : | ≥90% (SDS-PAGE). |
Formulation : | Liquid. 0.2μm-filtered solution in PBS. |
Concentration : | 250μg/ml. |
Endotoxin Content : | <1EU/µg protein (LAL-test). |
Long Term Storage : | -20°C. |
Use/Stability : | Working aliquots are stable for up to 3 months when stored at -20°C. |
Handling : | Avoid freeze/thaw cycles.After opening, prepare aliquots and store at -20°C. |
Gene Name : | Fgf21 fibroblast growth factor 21 [ Mus musculus ] |
Synonyms : | Fgf21; fibroblast growth factor 21;FGF-21 |
Gene ID : | 56636 |
mRNA Refseq : | NM_020013 |
Protein Refseq : | NP_064397 |
UniProt ID : | Q9JJN1 |
Chromosome Location : | 7 B2 |
Pathway : | MAPK signaling pathway; Melanoma; Pathways in cancer; Regulation of actin cytoskeleton |
Function : | growth factor activity |
Products Types
◆ Recombinant Protein | ||
FGF21-85H | Active Recombinant Human FGF21 Protein | +Inquiry |
Fgf21-931R | Recombinant Rat Fgf21 Protein, His-tagged | +Inquiry |
Fgf21-574M | Recombinant Mouse Fgf21 protein(Met1-Ser210), His-tagged | +Inquiry |
FGF21-287F | Active Recombinant Human FGF21 Protein, His-tagged | +Inquiry |
Fgf21-257M | Active Recombinant Mouse Fgf21 Protein (Ala29-Ser210), N-His tagged, Animal-free, Carrier-free | +Inquiry |
◆ Lysates | ||
FGF21-1890MCL | Recombinant Mouse FGF21 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewThe manufacturer's history of producing high-quality products contributed to our trust in this protein.
Collaboration with other research groups was made easier by the product's standardized use in the scientific community.
The product's role in promoting collaboration and teamwork positively impacted the quality of our research.
Q&As (7)
Ask a questionFGF21 expression in adipose tissue is regulated by various factors, including peroxisome proliferator-activated receptor gamma (PPARγ) activation.
FGF21 influences lipid metabolism by promoting the utilization of fatty acids for energy, contributing to the regulation of lipid homeostasis.
FGF21 levels are being explored as potential biomarkers for metabolic health, reflecting conditions such as insulin resistance and metabolic syndrome.
Yes, FGF21 plays a role in improving insulin sensitivity, making it a potential target for interventions in insulin resistance-associated conditions.
Yes, FGF21 influences energy expenditure by promoting thermogenesis in brown adipose tissue, contributing to overall metabolic regulation.
Gender-specific differences in FGF21 levels have been reported, with some studies suggesting higher circulating FGF21 concentrations in females.
FGF21 activates signaling pathways such as the AMP-activated protein kinase (AMPK) pathway, which contributes to its metabolic effects.
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