Recombinant Mouse Fibroblast Growth Factor 21, FLAG-tagged

Cat.No. : Fgf21-414M
Product Overview : Recombinant mouse fibroblast growth factor 21 (FGF-21) (aa 1-210) produced inHEK 293 cellsis fused at the C-terminus to a FLAG-tag.
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Cat. No. : Fgf21-414M
Description : FGF-21 is preferentially expressed in liver, but an exact knowledge of FGF-21 bioactivity and its mode of action have been lacking to date. FGF-21 is a potent activator of glucose uptake on adipocytes, protects animals from diet-induced obesity when overexpressed in transgenic mice, and lowers blood glucose and triglyceride levels when therapeutically administered to diabetic rodents.
Source/Host : HEK 293 cells.
Purity : ≥90% (SDS-PAGE).
Formulation : Liquid. 0.2μm-filtered solution in PBS.
Concentration : 250μg/ml.
Endotoxin Content : <1EU/µg protein (LAL-test).
Long Term Storage : -20°C.
Use/Stability : Working aliquots are stable for up to 3 months when stored at -20°C.
Handling : Avoid freeze/thaw cycles.After opening, prepare aliquots and store at -20°C.
Gene Name : Fgf21 fibroblast growth factor 21 [ Mus musculus ]
Synonyms : Fgf21; fibroblast growth factor 21;FGF-21
Gene ID : 56636
mRNA Refseq : NM_020013
Protein Refseq : NP_064397
UniProt ID : Q9JJN1
Chromosome Location : 7 B2
Pathway : MAPK signaling pathway; Melanoma; Pathways in cancer; Regulation of actin cytoskeleton
Function : growth factor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How is FGF21 expression regulated in adipose tissue? 10/31/2022

FGF21 expression in adipose tissue is regulated by various factors, including peroxisome proliferator-activated receptor gamma (PPARγ) activation.

What are the effects of FGF21 on lipid metabolism? 08/27/2020

FGF21 influences lipid metabolism by promoting the utilization of fatty acids for energy, contributing to the regulation of lipid homeostasis.

Can FGF21 be a biomarker for metabolic health? 08/07/2019

FGF21 levels are being explored as potential biomarkers for metabolic health, reflecting conditions such as insulin resistance and metabolic syndrome.

Is FGF21 involved in the regulation of insulin sensitivity? 03/03/2019

Yes, FGF21 plays a role in improving insulin sensitivity, making it a potential target for interventions in insulin resistance-associated conditions.

Does FGF21 have roles in energy expenditure? 11/11/2018

Yes, FGF21 influences energy expenditure by promoting thermogenesis in brown adipose tissue, contributing to overall metabolic regulation.

Are there gender-specific differences in FGF21 levels? 08/30/2017

Gender-specific differences in FGF21 levels have been reported, with some studies suggesting higher circulating FGF21 concentrations in females.

What signaling pathways does FGF21 activate? 01/09/2016

FGF21 activates signaling pathways such as the AMP-activated protein kinase (AMPK) pathway, which contributes to its metabolic effects.

Customer Reviews (3)

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Reviews
01/04/2022

    The manufacturer's history of producing high-quality products contributed to our trust in this protein.

    06/27/2021

      Collaboration with other research groups was made easier by the product's standardized use in the scientific community.

      03/03/2016

        The product's role in promoting collaboration and teamwork positively impacted the quality of our research.

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