||Mouse Flt3l (P49772, 144 amino acids) partial recombinant protein expressed in Escherichia coli.
||FMS-like tyrosine kinase 3 ligand (FLT3L) is an endogenous small molecule that functions as a cytokine and growth factor that increases the number of immune cells (lymphocytes (B cells and T cells)) by activating the hematopoietic progenitors. It acts by binding to and activating FLT3 (CD135) which is found on what (in mice) are called multipotent progenitor (MPP) and common lymphoid progenitor (CLP) cells. It also induces the mobilization of the hematopoietic progenitors and stem cells in vivo which may help the system to kill cancer cells.
||Determined by its ability to generate CD11c+ splenic dendritic cells in vivo in C57B1/6 mice (female, approx. 12 weeks old). To obtain the desired affect, mice were treated with approximately 25 μg of flt3-ligand once daily for 9 consecutive days
||< 0.1 ng/μg
||>= 98% by SDS-PAGE and HPLC
||Store at -20 centigrade on dry atmosphere. After reconstitution with sterilized water, store at -20 centigrade. Aliquot to avoid repeated freezing and thawing.