Recombinant Mouse Fnbp1 Protein, Myc/DDK-tagged

• Cat.No.: Fnbp1-3061M
• Product Overview: Purified recombinant protein of mouse full-length formin binding protein 1 (Fnbp1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May act as a link between RND2 signaling and regulation of the actin cytoskeleton. May be required for the lysosomal retention of FASLG/FASL.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 40 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Fnbp1 formin binding protein 1 [ Mus musculus (house mouse) ]
• Official Symbol: Fnbp1
• Synonyms: FNBP1; formin binding protein 1; formin-binding protein 1; formin binding protein 17; formin-binding protein 17; FBP1; Fbp17; 1110057E06Rik; 2210010H06Rik
• Gene ID: 14269
• mRNA Refseq: NM_019406
• Protein Refseq: NP_062279
• UniProt ID: Q80TY0