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Recombinant Mouse Fzr1 Protein, Myc/DDK-tagged

Cat.No. : Fzr1-3120M
Product Overview : Purified recombinant protein of mouse full-length fizzy and cell division cycle 20 related 1 (Fzr1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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Description : Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. Acts as an adapter for APC/C to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, may play a role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR).
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 55.1 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Fzr1 fizzy and cell division cycle 20 related 1 [ Mus musculus (house mouse) ]
Official Symbol : Fzr1
Synonyms : FZR1; fizzy/cell division cycle 20 related 1 (Drosophila); fizzy-related protein homolog; cdh1/Hct1 homolog; cell division cycle 20 related 1; FZR; Fyr; Cdh1; FZR2; HCDH; HCDH1; AW108046
Gene ID : 56371
mRNA Refseq : NM_019757
Protein Refseq : NP_062731
UniProt ID : Q9R1K5

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What is the function of FZR1 protein in the cell cycle? 10/06/2019

FZR1 protein plays a negative regulatory role in the cell cycle and is involved in mitosis and post-mitosis.

Why does knocking out FZR1 affect the cell cycle? 09/11/2019

This protein knockdown can lead to the disturbance of cell cycle regulation and affect the mitosis and post-mitosis of cells.

What are the post-translational modifications of FZR1 protein? 09/09/2019

FZR1 protein can undergo post-translational modifications such as phosphorylation and ubiquitination.

Which cyclins does the FZR1 protein interact with? 08/17/2019

This protein interacts with CDK1 (Cyclin-dependent kinase 1) and APC/C (Anaphase Promoting Complex/Cyclosome) protein complexes.

What is the expression pattern of FZR1 protein? 07/21/2019

The expression of FZR1 protein fluctuated during the cell cycle and was highly expressed in the late mitotic period.

Why does phosphorylation of FZR1 protein affect its function? 07/15/2019

The phosphorylation of FZR1 protein can regulate its interaction with other proteins and affect its function.

Customer Reviews (3)

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Reviews
05/05/2022

    Can be stored at room temperature for several days without deterioration, which allowed us to perform experiments easily and obtain reliable results.

    08/03/2020

      This protein is impressive and provides accurate and reliable experimental data for the research field.

      11/25/2019

        Green and environmentally friendly, with minimal harm to the human body. 0

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