Recombinant Full Length Human FZR1 Protein, C-Flag-tagged

• Cat.No.: FZR1-1049HFL
• Product Overview: Recombinant Full Length Human FZR1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: Predicted to enable anaphase-promoting complex binding activity and ubiquitin ligase activator activity. Involved in anaphase-promoting complex-dependent catabolic process; mitotic G2 DNA damage checkpoint signaling; and positive regulation of protein metabolic process. Located in nuclear membrane and nucleoplasm. Colocalizes with anaphase-promoting complex.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 54.6 kDa
• AA Sequence: MDQDYERRLLRQIVIQNENTMPRVT EMRRTLTPASSPVSSPSKHGDRFIP SRAGANWSVNFHRINENEKS PSQNRKAKDATSDNGKDGLAYSALL KNELLGAGIEKVQDPQTEDRRLQPS TPEKKGLFTYSLSTKRSSPD DGNDVSPYSLSPVSNKSQKLLRSPR KPTRKISKIPFKVLDAPELQDDFYL NLVDWSSLNVLSVGLGTCVY LWSACTSQVTRLCDLSVEGDSVTSV GWSERGNLVAVGTHKGFVQIWDAAA GKKLSMLEGHTARVGALAWN AEQLSSGSRDRMILQRDIRTPPLQS ERRLQGHRQEVCGLKWSTDHQLLAS GGNDNKLLVWNHSSLSPVQQ YTEHLAAVKAIAWSPHQHGLLASGG GTADRCIRFWNTLTGQPLQCIDTGS QVCNLAWSKHANELVSTHGY SQNQILVWKYPSLTQVAKLTGHSYR VLYLAMSPDGEAIVTGAGDETLRFW NVFSKTRSTKESVSVLNLFT
  RIRSGPTRTRPLEQKLISEEDLAAN DILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome
• Protein Pathways: Cell cycle, Progesterone-mediated oocyte maturation, Ubiquitin mediated proteolysis

Gene Information

• Gene Name: FZR1 fizzy and cell division cycle 20 related 1 [ Homo sapiens (human) ]
• Official Symbol: FZR1
• Synonyms: FZR; CDH1; FZR2; HCDH; HCDH1; CDC20C; DEE109
• Gene ID: 51343
• mRNA Refseq: NM_016263.4
• Protein Refseq: NP_057347.2
• MIM: 603619
• UniProt ID: Q9UM11