Recombinant Mouse Hic1 Protein, MYC/DDK-tagged Hic1-1125M

Recombinant Mouse Hic1 Protein, MYC/DDK-tagged

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Recombinant Mouse Hic1 Protein, MYC/DDK-tagged

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Cat.No. : Hic1-1125M
Product Overview : Purified recombinant protein of full-length mouse hypermethylated in cancer 1 (Hic1), with C-terminal MYC/DDK tag, was expressed in HEK293T cells.
Description : Transcriptional repressor. Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. May act as a tumor suppressor. May be involved in development of head, face, limbs and ventral body wall. Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses. The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1. The regulation of SIRT1 transcription in response to nutrient deprivation seems to involve CTBP1. In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells. Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes. Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex. Probably represses transcription from ACKR3, FGFBP1 and EFNA1.
Source : HEK293T
Species : Mouse
Tag : MYC/DDK
Molecular Mass : 77.3 kDa
Purity : >80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 µg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Hic1 hypermethylated in cancer 1 [ Mus musculus (house mouse) ]
Official Symbol : Hic1
Synonyms : Hic1; hypermethylated in cancer 1; HIC-1; AA408311; hypermethylated in cancer 1 protein
Gene ID : 15248
mRNA Refseq : NM_001098203
Protein Refseq : NP_001091673
UniProt ID : Q9R1Y5

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