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Recombinant Mouse Hmgb1 Protein, MYC/DDK-tagged

Cat.No. : Hmgb1-1134M
Product Overview : Purified recombinant protein of full-length mouse high mobility group box 1 (cDNA clone MGC:117897 IMAGE:5036554), complete cds, with C-terminal MYC/DDK tag, was expressed in HEK293T cells.
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  • Gene Information
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Description : This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants that encode the same protein.
Source : HEK293T
Species : Mouse
Tag : MYC/DDK
Molecular Mass : 24.9 kDa
Purity : >80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 µg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Hmgb1 high mobility group box 1 [ Mus musculus (house mouse) ]
Official Symbol : Hmgb1
Synonyms : Hmgb1; high mobility group box 1; p30; Hmg1; HMG-1; SBP-1; high mobility group protein B1; amphoterin; high mobility group protein 1
Gene ID : 15289
mRNA Refseq : NM_010439
Protein Refseq : NP_034569
UniProt ID : P63158

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Why is HMGB1 protein associated with tumors? 11/07/2019

This protein can promote tumor growth, invasion and angiogenesis, and plays an important role in tumor immune evasion.

Is HMGB1 protein involved in tumor metastasis? 11/05/2019

Yes, HMGB1 protein plays an important role in tumor metastasis, particularly by promoting invasion of tumor cells and migration of the hematopoietic system.

What is the association between HMGB1 protein and cardiovascular disease? 10/02/2019

Is involved in inflammatory response, vascular damage, and thrombosis in cardiovascular disease and may be associated with myocardial ischemia-reperfusion injury.

What is the effect of HMGB1 protein on the immune system? 08/31/2019

HMGB1 protein can promote the activation, chemotaxis and inflammatory response of immune cells, and is also involved in regulating the balance of autoimmune response.

What role does HMGB1 play in diabetes? 08/21/2019

HMGB1 protein is associated with processes such as chronic inflammation and insulin resistance in diabetes and may be a potential target for treatment and prevention.

Does HMGB1 play a role in liver disease? 08/15/2019

The protein is involved in pathological processes such as liver fibrosis, hepatitis, and liver cancer in liver disease and may be a target for therapeutic strategies.

Customer Reviews (3)

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Reviews
09/22/2021

    Broad storage conditions of HMGB1ins make the experimental process more stable and reliable, which provides a strong guarantee for scientific research.

    05/02/2020

      I found that tHMGB1 exhibited very good stability during storage, which allowed us to perform experiments easily and obtain reliable results.

      01/11/2019

        The anti-contamination ability of HMGB1 was excellent in Western blot, and the contamination problem in the experiment was avoided.

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