Recombinant Mouse ICOS protein (C137S, C138S), Fc-tagged ICOS-729M

Recombinant Mouse ICOS protein (C137S, C138S), Fc-tagged


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Recombinant Mouse ICOS protein (C137S, C138S), Fc-tagged

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Cat.No. : ICOS-729M Optional Service: Optional requirements on this protein
Product Overview : Recombinant Mouse ICOS (C137S (Glu21-Leu144) protein was fused to human IgG1 Fc tag at C-terminus and expressed in human 293 cells (HEK293).
Description : Inducible T-cell costimulator (ICOS) is also known as Activation-inducible lymphocyte immunomediatory molecule (AILIM), CD278, which belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1. ICOS enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. CD278/ICOS prevents the apoptosis of pre-activated T-cells and also plays a critical role in CD40-mediated class switching of immunoglobin isotypes.
Source : HEK293
Species : Mouse
Tag : human IgG1 Fc
Predicted N Terminal : Glu21
Form : Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5, 10% trehalose.
Molecular Mass : The protein has a calculated MW of 40.6 kDa. The protein migrates as 45-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Protein length : Glu21-Leu144
Endotoxin : Less than 1.0 EU per μg by the LAL method.
Purity : >95% as determined by SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents.

Mouse ICOS (C137S, C138S), Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

Bioactivity-ELISA of ICOS-729M :

Immobilized Human B7-H2, His Tag at 1 μg/mL (100 μL/well) can bind Mouse ICOS (C137S, C138S), Fc Tag with a linear range of 0.3-10 ng/mL (QC tested).

Gene Name : ICOS
Official Symbol : ICOS
Synonyms : ICOS; inducible T cell co-stimulator; inducible T-cell costimulator; CD28-related protein 1; CD28 and CTLA-4-like protein; inducible T-cell co-stimulator; activation-inducible lymphocyte immunomediatory molecule; H4; CCLP; AILIM; CRP-1; Ly115
Gene ID : 54167
mRNA Refseq : NM_017480
Protein Refseq : NP_059508
UniProt ID : Q9WVS0
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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