Recombinant Mouse ICOS protein (C137S, C138S), Fc-tagged
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|Product Overview :||Recombinant Mouse ICOS (C137S (Glu21-Leu144) protein was fused to human IgG1 Fc tag at C-terminus and expressed in human 293 cells (HEK293).|
|Description :||Inducible T-cell costimulator (ICOS) is also known as Activation-inducible lymphocyte immunomediatory molecule (AILIM), CD278, which belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1. ICOS enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. CD278/ICOS prevents the apoptosis of pre-activated T-cells and also plays a critical role in CD40-mediated class switching of immunoglobin isotypes.|
|Tag :||human IgG1 Fc|
|Predicted N Terminal :||Glu21|
|Form :||Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5, 10% trehalose.|
|Molecular Mass :||The protein has a calculated MW of 40.6 kDa. The protein migrates as 45-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.|
|Protein length :||Glu21-Leu144|
|Endotoxin :||Less than 1.0 EU per μg by the LAL method.|
|Purity :||>95% as determined by SDS-PAGE.|
For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
|Reconstitution :||It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents.|
|SDS-PAGE of ICOS-729M :||
Mouse ICOS (C137S, C138S), Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
|Bioactivity-ELISA of ICOS-729M :||
Immobilized Human B7-H2, His Tag at 1 μg/mL (100 μL/well) can bind Mouse ICOS (C137S, C138S), Fc Tag with a linear range of 0.3-10 ng/mL (QC tested).
|Gene Name :||ICOS|
|Official Symbol :||ICOS|
|Synonyms :||ICOS; inducible T cell co-stimulator; inducible T-cell costimulator; CD28-related protein 1; CD28 and CTLA-4-like protein; inducible T-cell co-stimulator; activation-inducible lymphocyte immunomediatory molecule; H4; CCLP; AILIM; CRP-1; Ly115|
|Gene ID :||54167|
|mRNA Refseq :||NM_017480|
|Protein Refseq :||NP_059508|
|UniProt ID :||Q9WVS0|
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