Recombinant Mouse ICOS protein (C137S, C138S), Fc-tagged

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Recombinant Mouse ICOS protein (C137S, C138S), Fc-tagged

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Cat.No. : ICOS-729M
Product Overview : Recombinant Mouse ICOS (C137S (Glu21-Leu144) protein was fused to human IgG1 Fc tag at C-terminus and expressed in human 293 cells (HEK293).
Description : Inducible T-cell costimulator (ICOS) is also known as Activation-inducible lymphocyte immunomediatory molecule (AILIM), CD278, which belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1. ICOS enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. CD278/ICOS prevents the apoptosis of pre-activated T-cells and also plays a critical role in CD40-mediated class switching of immunoglobin isotypes.
Source : HEK293
Species : Mouse
Tag : human IgG1 Fc
Predicted N Terminal : Glu21
Form : Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5, 10% trehalose.
Molecular Mass : The protein has a calculated MW of 40.6 kDa. The protein migrates as 45-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Protein length : Glu21-Leu144
Endotoxin : Less than 1.0 EU per μg by the LAL method.
Purity : >95% as determined by SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents.
SDS-PAGE of ICOS-729M :

Mouse ICOS (C137S, C138S), Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

Bioactivity-ELISA of ICOS-729M :

Immobilized Human B7-H2, His Tag at 1 μg/mL (100 μL/well) can bind Mouse ICOS (C137S, C138S), Fc Tag with a linear range of 0.3-10 ng/mL (QC tested).

Gene Name : ICOS
Official Symbol : ICOS
Synonyms : ICOS; inducible T cell co-stimulator; inducible T-cell costimulator; CD28-related protein 1; CD28 and CTLA-4-like protein; inducible T-cell co-stimulator; activation-inducible lymphocyte immunomediatory molecule; H4; CCLP; AILIM; CRP-1; Ly115
Gene ID : 54167
mRNA Refseq : NM_017480
Protein Refseq : NP_059508
UniProt ID : Q9WVS0

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