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Recombinant Mouse ICOS Protein (Met1-Leu144), RlgG Fc-tagged

Cat.No. : ICOS-827M
Product Overview : Recombinant Mouse ICOS Protein (NP_059508.2) (Met1-Leu144) was produced by HEK293 Cells expression system. This protein was expressed with the Fc region of rabbit IgG at the C-terminus.
Description : Inducible costimulator (ICOS), also called AILIM (activiation-inducible lymphocyte immunomediatory molecule) is a cell-surface receptor, and belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1. The interaction of B7-H2/ICOS plays a critical role in Th cell differentiation, T−B cell interactions which is essential for germinal center formation, and humoral immune responses, and as well as the production of cytokine IL-4. In addition, ICOS is more potent in the induction of IL-1 production, a cytokine important for suppressive function of T regulatory cells. The B7-1/B7-2--CD28/CTLA-4 and ICOS-B7RP-1 pathway provides key second signals that can regulate the activation, inhibition and fine-tuning of T-lymphocyte responses. ICOS stimulates both Th1 and Th2 cytokine production but may have a preferential role in Th2 cell development. Moreover, The B7-1/B7-2-CD28/CTLA-4 and ICOS-B7RP-1 pathway has been suggested of being involved in the development of airway inflammation and airway hyperresponsiveness.
Source : HEK293
Species : Mouse
Tag : RlgG Fc
Predicted N Terminal : Glu 21
Form : Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Molecular Mass : The recombinant mouse Icos consists of 355 amino acids and predicts a molecular mass of 40.2 kDa.
Protein length : Met1-Leu144
Endotoxin : < 1.0 EU per μg protein as determined by the LAL method.
Purity : > 90 % as determined by SDS-PAGE.
Stability : Samples are stable for up to twelve months from date of receipt at -70 centigrade.
Storage : Store it under sterile conditions at -20 centigrade to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 mg/ml. Centrifuge the vial at 4ºC before opening to recover the entire contents.
Shipping : In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Gene Name : Icos inducible T cell co-stimulator [ Mus musculus ]
Official Symbol : ICOS
Synonyms : ICOS; H4; CCLP; AILIM; CRP-1; Ly115;
Gene ID : 54167
mRNA Refseq : NM_017480
Protein Refseq : NP_059508
UniProt ID : Q5SUZ7

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