| Description : |
This gene encodes a pro-inflammatory cytokine that is a member of the interleukin-17 family. The encoded protein plays a central role in host defense against diverse pathogens. The encoded protein is produced by activated T-cells and certain cell types of innate immune system. The active protein functions as either a homodimer with other interleukin-17 family members and signals through the interleukin-17 receptor to induce inflammatory cytokine production. Aberrant expression of this gene is associated with autoinflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. |
| Source : |
E. coli |
| Species : |
Mouse |
| Bio-activity : |
The ED50 is 0.25 - 1 ng/ml, corresponding to a specific activity 1.0 - 4 x 10^6 units/mg, determined by a dose dependent stimulation of fetal mouse skin fibroblasts production of IL-6. |
| Molecular Mass : |
15 kDa |
| Endotoxin : |
Less than 0.01 ng per µg protein as determined by the LAL method |
| Purity : |
>98%, as determined by Coomassie stained SDS-PAGE. |
| Stability : |
Unopened vial can be stored between 2 centigrade and 8 centigrade for up to 2 weeks, at -20 centigrade for up to 6 months, or at -70 centigrade or below until the expiration date. Aliquots can be stored between 2 centigrade and 8 centigrade for up to one week and stored at -20 centigrade or colder for up to 3 months. Avoid repeated freeze/thaw cycles. |
| Storage : |
Store at -80 centigrade. |
| Concentration : |
Protein formulated and vialed at >50 ug/mL in specified buffer |
| Storage Buffer : |
10 mM NaH2PO4, 0.15 M NaCl, pH7.2 |
