Recombinant Mouse IL1RL2 Protein (22-338 aa), His-tagged

Cat.No. : IL1RL2-1983M
Product Overview : Recombinant Mouse IL1RL2 Protein (22-338 aa) is produced by E. coli expression system. This protein is fused with a 6xHis tag at the N-terminal. Research Area: Immunology. Protein Description: Partial.
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Description : Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways. The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway.
Source : E. coli
Species : Mouse
Tag : His
Form : Tris-based buffer,50% glycerol
Molecular Mass : 40.0 kDa
Protein length : 22-338 aa
AA Sequence : DTCEDIFMHNVIISEGQPFPFNCTY PPETNGAVNLTWYKTPSKSPVSNNR HLRVHQDQTWILFLPLTLEDSGIYQ CVIRNAHNCYQIAVNLTVLKNHWCD SSMEGSPVNSPDVYQQILPIGKSGS LNCHLYFPESCALDSIKWYKGCEEI KAGKKYSPSGAKLLVNNVAVEDGGS YACSARLTHLGRHFTIRNYIAVNTK EVEYGRRIPNITYPKNNSIEVPLGS TLIVNCNITDTKENTNLRCWRVNNT LVDDYYKDSKRIQEGIETNVSLRDQ IRYTVNITFLKVKMEDYGRPFTCHA GVSAAYIILIYPVPDFR
Purity : > 90% as determined by SDS-PAGE.
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
Concentration : A hardcopy of COA with reconstitution instruction is sent along with the products.
Gene Name : Il1rl2 interleukin 1 receptor-like 2 [ Mus musculus ]
Official Symbol : IL1RL2
Synonyms : IL1RL2; IL1R-rp2; AI481289; AW551444; IL-1Rrp2;
Gene ID : 107527
mRNA Refseq : NM_133193
Protein Refseq : NP_573456
UniProt ID : Q9ERS7

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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What is the role of Il1rl2 in cardiac hypertrophy? 05/10/2020

Il1rl2 is involved in the development of cardiac hypertrophy.

How does Il1rl2 expression change in response to bacterial infection? 01/01/2019

Il1rl2 expression is upregulated in response to bacterial infection.

How does Il1rl2 affect macrophage polarization? 12/21/2018

Il1rl2 induces M2 macrophage polarization.

What is the affinity of Il1rl2 for its primary ligand? 09/08/2018

Il1rl2 has high affinity for its primary ligand, IL-36.

What is the role of Il1rl2 in adipogenesis? 05/14/2018

Il1rl2 promotes adipogenesis by activating PPAR-gamma.

What is the half-life of Il1rl2 in serum? 05/11/2018

The half-life of Il1rl2 in serum is approximately 30 minutes.

Does Il1rl2 interact with any membrane receptors? 03/15/2018

Il1rl2 interacts with IL-36R on the cell membrane.

Does Il1rl2 undergo post-translational modifications? 12/28/2017

Il1rl2 undergoes phosphorylation.

Does Il1rl2 contribute to the blood-brain barrier permeability? 12/06/2016

Il1rl2 increases blood-brain barrier permeability.

Is Il1rl2 expression influenced by circadian rhythms? 09/28/2016

Il1rl2 expression is not influenced by circadian rhythms.

Customer Reviews (3)

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Reviews
11/17/2022

    High purity. -

    03/07/2019

      Good for receptor binding. -

      10/14/2018

        Effective in inflammation assays. -

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