Recombinant Mouse IL1RL2 Protein (22-338 aa), His-tagged
|Product Overview :||Recombinant Mouse IL1RL2 Protein (22-338 aa) is produced by E. coli expression system. This protein is fused with a 6xHis tag at the N-terminal. Research Area: Immunology. Protein Description: Partial.|
- Gene Information
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|Description :||Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways. The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway.|
|Source :||E. coli|
|Form :||Tris-based buffer,50% glycerol|
|Molecular Mass :||40.0 kDa|
|Protein length :||22-338 aa|
|AA Sequence :||DTCEDIFMHNVIISEGQPFPFNCTY PPETNGAVNLTWYKTPSKSPVSNNR HLRVHQDQTWILFLPLTLEDSGIYQ CVIRNAHNCYQIAVNLTVLKNHWCD SSMEGSPVNSPDVYQQILPIGKSGS LNCHLYFPESCALDSIKWYKGCEEI KAGKKYSPSGAKLLVNNVAVEDGGS YACSARLTHLGRHFTIRNYIAVNTK EVEYGRRIPNITYPKNNSIEVPLGS TLIVNCNITDTKENTNLRCWRVNNT LVDDYYKDSKRIQEGIETNVSLRDQ IRYTVNITFLKVKMEDYGRPFTCHA GVSAAYIILIYPVPDFR|
|Purity :||> 90% as determined by SDS-PAGE.|
|Notes :||Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.|
|Storage :||The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.|
|Concentration :||A hardcopy of COA with reconstitution instruction is sent along with the products.|
|Gene Name :||Il1rl2 interleukin 1 receptor-like 2 [ Mus musculus ]|
|Official Symbol :||IL1RL2|
|Synonyms :||IL1RL2; IL1R-rp2; AI481289; AW551444; IL-1Rrp2;|
|Gene ID :||107527|
|mRNA Refseq :||NM_133193|
|Protein Refseq :||NP_573456|
|UniProt ID :||Q9ERS7|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (10)Ask a question
Il1rl2 is involved in the development of cardiac hypertrophy.
Il1rl2 expression is upregulated in response to bacterial infection.
Il1rl2 induces M2 macrophage polarization.
Il1rl2 has high affinity for its primary ligand, IL-36.
Il1rl2 promotes adipogenesis by activating PPAR-gamma.
The half-life of Il1rl2 in serum is approximately 30 minutes.
Il1rl2 interacts with IL-36R on the cell membrane.
Il1rl2 undergoes phosphorylation.
Il1rl2 increases blood-brain barrier permeability.
Il1rl2 expression is not influenced by circadian rhythms.
Customer Reviews (3)Write a review
High purity. -
Good for receptor binding. -
Effective in inflammation assays. -
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