Recombinant Mouse Il1rn protein
| Cat.No. : | Il1rn-546M |
| Product Overview : | Recombinant Mouse Il1rn protein was expressed in Escherichia coli. |
- Specification
- Gene Information
- Related Products
| Description : | IL-1RA was initially called the IL-1 inhibitor which is encoded by the IL1RN gene and it is a member of the interleukin 1 cytokine family. IL-1RA is secreted by various types of cells including immune cells, epithelial cells, and adipocytes. IL-RA has functions of inhibiting the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. IL-1RA is also used in the treatment of rheumatoid arthritis, an autoimmune disease in which IL-1 plays a key role. The murine IL-1RA is a single non-glycosylated polypeptide chain containing 152 amino acids and it has been shown to block the inflammatory responses induced by IL-1 both in vitro and in vivo. The protein shows 26 % amino acid homology to IL-1β and 19% homology to IL-1α. It also shares 90 % a.a. sequence identity with rat IL-1RA. |
| Source : | E.coli |
| Species : | Mouse |
| Form : | Lyophilized from a 0.2μm filtered concentrated solution in PBS, pH 7.4. |
| Bio-activity : | Fully biologically active when compared to standard. The ED50 as determined by inhibiting IL-1α-dependent proliferation of murine D10S cells is less than 50 ng/ml, corresponding to a specific activity of > 2.0 × 10⁴ IU/mg in the presence of 50 pg/ml rHuIL-1α. |
| Molecular Mass : | Approximately 17.3 kDa, a single non-glycosylated polypeptide chain containing 152 amino acids. |
| Protein length : | 152 |
| AA Sequence : | RPSGKRPCKMQAFRIWDTNQKTFYL RNNQLIAGYLQGPNIKLEEKIDMVP IDLHSVFLGIHGGKLCLSCAKSGDD IKLQLEEVNITDLSKNKEEDKRFTF IRSEKGPTTSFESAACPGWFLCTTL EADRPVSLTNTPEEPLIVTKFYFQE DQ |
| Endotoxin : | Less than 1 EU/µg of rMuIL-1RA as determined by LAL method. |
| Purity : | >97% by SDS-PAGE and HPLC analysis. |
| Storage : | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution. |
| Reconstitution : | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤-20 centigrade. Further dilutions should be made in appropriate buffered solutions. |
| Gene Name : | Il1rn |
| Official Symbol : | Il1rn |
| Synonyms : | IL1RN; interleukin 1 receptor antagonist; interleukin-1 receptor antagonist protein; IRAP; IL-1RN; IL1 inhibitor; IL-1ra; F630041P17Rik; |
| Gene ID : | 16181 |
| mRNA Refseq : | NM_001039701 |
| Protein Refseq : | NP_001034790 |
| UniProt ID : | Q542W1 |
Products Types
| ◆ Recombinant Protein | ||
| IL1RN-183I | Active Recombinant Human IL1RN Protein | +Inquiry |
| Il1rn-2299R | Recombinant Rat Il1rn Protein, His-tagged | +Inquiry |
| IL1RN-167H | Recombinant Active Human IL1RN Protein, His-tagged(C-ter) | +Inquiry |
| IL1RN-103I | Active Recombinant Human IL1RN Protein (153 aa) | +Inquiry |
| IL1RN-2692R | Recombinant Rat IL1RN Protein, His (Fc)-Avi-tagged | +Inquiry |
| ◆ Lysates | ||
| IL1RN-2912HCL | Recombinant Human IL1RN cell lysate | +Inquiry |
| IL1RN-1375RCL | Recombinant Rat IL1RN cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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