Recombinant Mouse Itga4 Protein, Myc/DDK-tagged
Cat.No. : | Itga4-3595M |
Product Overview : | Purified recombinant protein of mouse full-length integrin alpha 4 (Itga4), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
- Specification
- Gene Information
- Related Products
Description : | Integrins alpha-4/beta-1 (VLA-4 or LPAM-2) and alpha-4/beta-7 (LPAM-1) are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGA4:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 115.5 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Itga4 integrin alpha 4 [ Mus musculus (house mouse) ] |
Official Symbol : | Itga4 |
Synonyms : | ITGA4; integrin alpha 4; integrin alpha-4; integrin alpha-IV; LPAM subunit alpha; VLA-4 subunit alpha; VLA-4 receptor, alpha 4 subunit; CD49 antigen-like family member D; lymphocyte Peyer patch adhesion molecules subunit alpha; CD49D |
Gene ID : | 16401 |
mRNA Refseq : | NM_010576 |
Protein Refseq : | NP_034706 |
UniProt ID : | Q00651 |
Products Types
◆ Recombinant Protein | ||
ITGA4-4998H | Recombinant Human ITGA4 Protein | +Inquiry |
ITGA4-1210H | Recombinant Human ITGA4 Protein, His (Fc)-Avi-tagged | +Inquiry |
ITGA4-2340H | Recombinant Human ITGA4 Protein, His-tagged | +Inquiry |
Itga4-1696M | Recombinant Mouse Itga4 Protein, His-tagged | +Inquiry |
ITGA4-4637M | Recombinant Mouse ITGA4 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
ITGA4-5133HCL | Recombinant Human ITGA4 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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