Recombinant Mouse Kctd6 Protein, Myc/DDK-tagged

• Cat.No.: Kctd6-3675M
• Product Overview: Purified recombinant protein of mouse full-length potassium channel tetramerisation domain containing 6 (Kctd6), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1; the function seems to depend on KCTD11:KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Involved in regulating protein levels of ANK1 isoform Mu7 probably implicating CUL3-dependent proteasomal degradation.
• Molecular Mass: 27.6 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Kctd6 potassium channel tetramerisation domain containing 6 [ Mus musculus (house mouse) ]
• Official Symbol: Kctd6
• Synonyms: KCTD6; potassium channel tetramerisation domain containing 6; BTB/POZ domain-containing protein KCTD6; AU044285; 5430433B02Rik
• Gene ID: 71393
• mRNA Refseq: NM_027782
• Protein Refseq: NP_082058
• UniProt ID: Q8BNL5