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Recombinant Mouse L3mbtl1 Protein, Myc/DDK-tagged

Cat.No. : L3mbtl1-3743M
Product Overview : Purified recombinant protein of mouse full-length L3MBTL1 histone methyl-lysine binding protein (L3mbtl1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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Description : Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/H1-4 at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 92.2 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : L3mbtl1 L3MBTL1 histone methyl-lysine binding protein [ Mus musculus (house mouse) ]
Official Symbol : L3mbtl1
Synonyms : L3MBTL1; l(3)mbt-like (Drosophila); lethal(3)malignant brain tumor-like protein 1; H-l(3)mbt protein; L(3)mbt protein homolog; L3mbtl; mKIAA0681; C630004G01; KIAA0681
Gene ID : 241764
mRNA Refseq : NM_001081338
Protein Refseq : NP_001074807
UniProt ID : A2A5N8

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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