Recombinant Mouse Lamtor4 Protein, Myc/DDK-tagged

• Cat.No.: Lamtor4-3751M
• Product Overview: Purified recombinant protein of mouse full-length late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 (Lamtor4), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.
• Molecular Mass: 11.1 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Lamtor4 late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 [ Mus musculus (house mouse) ]
• Official Symbol: Lamtor4
• Synonyms: Lamtor4; late endosomal/lysosomal adaptor, MAPK and MTOR activator 4; AV006840; 0910001L09Rik; ragulator complex protein LAMTOR4; UPF0539 protein C7orf59 homolog; late endosomal/lysosomal adaptor and MAPK and MTOR activator 4
• Gene ID: 66096
• mRNA Refseq: NM_001081108
• Protein Refseq: NP_001074577
• UniProt ID: Q8CF66