Recombinant Mouse Maml1 Protein, MYC/DDK-tagged Maml1-238M

Recombinant Mouse Maml1 Protein, MYC/DDK-tagged

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Recombinant Mouse Maml1 Protein, MYC/DDK-tagged

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Cat.No. : Maml1-238M
Product Overview : Purified recombinant protein of full-length mouse mastermind like transcriptional coactivator 1 (Maml1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
Description : Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.
Source : HEK293T
Species : Mouse
Tag : MYC/DDK
Molecular Mass : 108.2 kDa
Purity : >80%, as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 ug/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Maml1 mastermind like transcriptional coactivator 1 [ Mus musculus (house mouse) ]
Official Symbol : Maml1
Synonyms : Maml1; mastermind like transcriptional coactivator 1; Mam1; Mam-1; AI644666; AW743257; mKIAA0200; D930008C07Rik; mastermind-like protein 1; maml1; mastermind like 1
Gene ID : 103806
mRNA Refseq : NM_175334
Protein Refseq : NP_780543
UniProt ID : Q6T264

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