Recombinant Mouse Maml1 Protein, MYC/DDK-tagged


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Recombinant Mouse Maml1 Protein, MYC/DDK-tagged

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Cat.No. : Maml1-238M
Product Overview : Purified recombinant protein of full-length mouse mastermind like transcriptional coactivator 1 (Maml1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
Description : Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.
Source : HEK293T
Species : Mouse
Molecular Mass : 108.2 kDa
Purity : >80%, as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 ug/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Maml1 mastermind like transcriptional coactivator 1 [ Mus musculus (house mouse) ]
Official Symbol : Maml1
Synonyms : Maml1; mastermind like transcriptional coactivator 1; Mam1; Mam-1; AI644666; AW743257; mKIAA0200; D930008C07Rik; mastermind-like protein 1; maml1; mastermind like 1
Gene ID : 103806
mRNA Refseq : NM_175334
Protein Refseq : NP_780543
UniProt ID : Q6T264
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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