Recombinant Mouse Mapkap1 Protein, Myc/DDK-tagged
Cat.No. : | Mapkap1-3949M |
Product Overview : | Purified recombinant protein of mouse full-length mitogen-activated protein kinase associated protein 1 (Mapkap1), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
- Specification
- Gene Information
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Description : | Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Isoform 1 is involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 59.5 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Mapkap1 mitogen-activated protein kinase associated protein 1 [ Mus musculus (house mouse) ] |
Official Symbol : | Mapkap1 |
Synonyms : | MAPKAP1; mitogen-activated protein kinase associated protein 1; target of rapamycin complex 2 subunit MAPKAP1; TORC2 subunit MAPKAP1; SAPK-interacting protein 1; stress-activated map kinase-interacting protein 1; mitogen activated protein kinase associated protein 1; mitogen-activated protein kinase 2-associated protein 1; Sin1; AI591529; D230039K05Rik |
Gene ID : | 227743 |
mRNA Refseq : | NM_177345 |
Protein Refseq : | NP_796319 |
UniProt ID : | Q8BKH7 |
Products Types
◆ Recombinant Protein | ||
MAPKAP1-1797H | Recombinant Human MAPKAP1 Protein (2-522 aa), His-SUMO-tagged | +Inquiry |
MAPKAP1-1365H | Recombinant Human MAPKAP1 Protein, His (Fc)-Avi-tagged | +Inquiry |
MAPKAP1-5355M | Recombinant Mouse MAPKAP1 Protein, His (Fc)-Avi-tagged | +Inquiry |
MAPKAP1-1763H | Recombinant Human MAPKAP1 Protein, His&GST-tagged | +Inquiry |
MAPKAP1-3233R | Recombinant Rat MAPKAP1 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
MAPKAP1-4483HCL | Recombinant Human MAPKAP1 293 Cell Lysate | +Inquiry |
MAPKAP1-4484HCL | Recombinant Human MAPKAP1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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