| Description : |
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. |
| Source : |
Yeast |
| Species : |
Mouse |
| Tag : |
His |
| Form : |
Tris-based buffer, 50% glycerol |
| Molecular Mass : |
78.11kDa |
| AA Sequence : |
ADPRQEFDTMEDHAGDYTLLQDQEG DMDHGLKESPPQPPADDGAEEPGSE TSDAKSTPTAEDVTAPLVDERAPDK QAAAQPHTEIPEGITAEEAGIGDTP NQEDQAAGHVTQGRREGQAPDLGTS DWTRQQVSSMSGAPLLPQGLREATC QPSGTRPEDIEKSHPASELLRRGPP QKEGWGQDRLGSEEEVDEDLTVDES SQDSPPSQASLTPGRAAPQAGSGSV CGETASVPGLPTEGSVPLPADFFSK VSAETQASQPEGPGTGPMEEGHEAA PEFTFHVEIKASTPKEQDLEGATVV GVPGEEQKAQTQGPSVGKGTKEASL QEPPGKQPAAGLPGRPVSRVPQLKA RVASKDRTGNDEKKAKTSTPSCAKA PSHRPCLSPTRPTLGSSDPLIKPSS PAVSPEPATSPKHVSSVTPRNGSPG TKQMKLKGADGKTGAKIATPRGAAS PAQKGTSNATRIPAKTTPSPKTPPG SGEPPKSGERSGYSSPGSPGTPGSR SRTPSLPTPPTREPKKVAVVRTPPK SPSASKSRLQTAPVPMPDLKNVRSK IGSTENLKHQPGGGKVQIINKKLDL SNVQSKCGSKDNIKHVPGGGSVQIV YKPVDLSKVTSKCGSLGNIHHKPGG GQVEVKSEKLDFKDRVQSKIGSLDN ITHVPGGGNKKIETHKLTFRENAKA KTDHGAEIVYKSPVVSGDTSPRHLS NVSSTGSIDMVDSPQLATLADEVSA SLAKQGL |
| Purity : |
>85% (SDS-PAGE) |
| Notes : |
Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week. |
| Storage : |
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade. |
