Recombinant Mouse Numbl Protein, Myc/DDK-tagged
Cat.No. : | Numbl-4548M |
Product Overview : | Purified recombinant protein of mouse full-length numb-like (Numbl), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
- Specification
- Gene Information
- Related Products
Description : | Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 64.1 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Numbl numb-like [ Mus musculus (house mouse) ] |
Official Symbol : | Numbl |
Synonyms : | NUMBL; numb-like; numb-like protein; nbl |
Gene ID : | 18223 |
mRNA Refseq : | NM_010950 |
Protein Refseq : | NP_035080 |
UniProt ID : | O08919 |
Products Types
◆ Recombinant Protein | ||
NUMBL-3700H | Recombinant Human NUMBL Protein, His (Fc)-Avi-tagged | +Inquiry |
NUMBL-1981H | Recombinant Human NUMBL Protein, MYC/DDK-tagged | +Inquiry |
NUMBL-1411H | Recombinant Human NUMBL, GST-tagged | +Inquiry |
NUMBL-5304H | Recombinant Human NUMBL Protein (Ala60-Lys204), N-His tagged | +Inquiry |
NUMBL-673H | Recombinant Human NUMBL | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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