Recombinant Mouse Pim3 Protein, Myc/DDK-tagged

• Cat.No.: Pim3-4870M
• Product Overview: Purified recombinant protein of mouse full-length proviral integration site 3 (Pim3), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis and promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression and protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 36.4 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Pim3 proviral integration site 3 [ Mus musculus (house mouse) ]
• Official Symbol: Pim3
• Synonyms: PIM3; proviral integration site 3; serine/threonine-protein kinase pim-3; KID-1/kinase induced by depolarization; Kid1; BC026639; MGC27707; MGC37517
• Gene ID: 223775
• mRNA Refseq: NM_145478
• Protein Refseq: NP_663453
• UniProt ID: P58750