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Recombinant Mouse Plxna1 Protein, Myc/DDK-tagged

Cat.No. : Plxna1-4948M
Product Overview : Purified recombinant protein of mouse full-length plexin A1 (Plxna1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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Description : Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 211.5 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Plxna1 plexin A1 [ Mus musculus (house mouse) ]
Official Symbol : Plxna1
Synonyms : PLXNA1; plexin A1; plexin-A1; plex 1; plexin 1; plexin-1; NOV; Plxn1; PlexA1; mKIAA4053; 2600013D04Rik; KIAA4053
Gene ID : 18844
mRNA Refseq : NM_008881
Protein Refseq : NP_032907
UniProt ID : P70206

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What role does PLXNA1 play in synaptic formation? 06/23/2023

PLXNA1 plays a role in the formation of synapses, essential for effective neural communication.

How does PLXNA1 interact with other signaling molecules in neural pathways? 10/29/2022

PLXNA1 interacts with various signaling molecules, coordinating complex neural development processes.

What is the impact of altered PLXNA1 activity on neurodevelopmental disorders? 05/22/2022

Altered PLXNA1 activity is linked to neurodevelopmental disorders due to its role in neuronal guidance and synapse formation.

What is the primary role of PLXNA1 in neural development? 02/08/2022

PLXNA1, a receptor in the plexin family, is crucial for neuronal development and pathway formation.

What potential therapeutic applications arise from targeting PLXNA1 in neurological conditions? 10/12/2019

Targeting PLXNA1 offers potential for treating conditions related to neural development and connectivity.

How does PLXNA1 contribute to axon guidance? 10/02/2018

It guides axon growth and direction, influencing the wiring of the nervous system.

How do genetic variations in PLXNA1 affect neural connectivity? 03/26/2018

Genetic mutations in PLXNA1 can disrupt neural pathways, affecting brain structure and function.

Customer Reviews (3)

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05/30/2023

    Critical for decision-making, a research necessity.

    03/26/2022

      Expert service quality, a trusted research ally.

      04/28/2021

        Consistent and trustworthy, boosts our research credibility.

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