Recombinant Mouse Psenen Protein, Myc/DDK-tagged

• Cat.No.: Psenen-5172M
• Product Overview: Purified recombinant protein of mouse full-length presenilin enhancer gamma secretase subunit (Psenen), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable). PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity.
• Molecular Mass: 12 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Psenen presenilin enhancer gamma secretase subunit [ Mus musculus (house mouse) ]
• Official Symbol: Psenen
• Synonyms: PSENEN; presenilin enhancer 2 homolog (C. elegans); gamma-secretase subunit PEN-2; presenilin enhancer protein 2; 1700023M09Rik; MGC102026
• Gene ID: 66340
• mRNA Refseq: NM_025498
• Protein Refseq: NP_079774
• UniProt ID: Q9CQR7