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Recombinant Mouse Ptpn11 Protein, Myc/DDK-tagged

Cat.No. : Ptpn11-5235M
Product Overview : Purified recombinant protein of mouse full-length protein tyrosine phosphatase, non-receptor type 11 (Ptpn11), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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Description : Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway. Dephosphorylates GAB1, ARHGAP35 and EGFR. Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity. Dephosphorylates CDC73. Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 68.5 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Ptpn11 protein tyrosine phosphatase, non-receptor type 11 [ Mus musculus (house mouse) ]
Official Symbol : Ptpn11
Synonyms : PTPN11; protein tyrosine phosphatase, non-receptor type 11; tyrosine-protein phosphatase non-receptor type 11; protein-tyrosine phosphatase SYP; SH2 domain-containing protein tyrosine phosphatase-2; Syp; Shp2; PTP1D; PTP2C; SAP-2; SHP-2; SH-PTP2; SH-PTP3; AW536184; 2700084A17Rik
Gene ID : 19247
mRNA Refseq : NM_011202
Protein Refseq : NP_035332
UniProt ID : P35235

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there genetic tests available to detect PTPN11 mutations? 12/17/2022

Yes, genetic testing can identify mutations in the PTPN11 gene, providing valuable information for diagnosis and treatment planning.

How does PTPN11 impact cell signaling pathways? 06/21/2022

PTPN11 is involved in various signaling pathways, including the RAS-MAPK pathway, and its mutations can dysregulate these pathways, leading to abnormal cell signaling.

Is PTPN11 involved in normal cellular functions? 02/20/2022

Yes, PTPN11 plays a crucial role in normal cellular functions by regulating the activity of proteins through dephosphorylation.

Can PTPN11 be used as a biomarker for certain diseases? 10/27/2020

Yes, the presence of PTPN11 mutations can serve as a biomarker for specific cancers and developmental disorders.

How is PTPN11 involved in developmental disorders? 02/04/2018

Mutations in PTPN11 can lead to developmental disorders, including Noonan syndrome and LEOPARD syndrome, affecting growth and development.

Customer Reviews (3)

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Reviews
08/01/2020

    Their technical expertise and knowledge of the PTPN11 protein are invaluable resources.

    05/18/2016

      This reliability reduces experimental variability and enhances the accuracy of data interpretation.

      04/11/2016

        the manufacturer's commitment to continuous innovation and development of new tools and technologies ensures that I have access to the latest advancements in PTPN11 protein research.

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