Recombinant Mouse Ptpn11 Protein, Myc/DDK-tagged
Cat.No. : | Ptpn11-5235M |
Product Overview : | Purified recombinant protein of mouse full-length protein tyrosine phosphatase, non-receptor type 11 (Ptpn11), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
- Specification
- Gene Information
- Related Products
Description : | Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway. Dephosphorylates GAB1, ARHGAP35 and EGFR. Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity. Dephosphorylates CDC73. Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 68.5 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Ptpn11 protein tyrosine phosphatase, non-receptor type 11 [ Mus musculus (house mouse) ] |
Official Symbol : | Ptpn11 |
Synonyms : | PTPN11; protein tyrosine phosphatase, non-receptor type 11; tyrosine-protein phosphatase non-receptor type 11; protein-tyrosine phosphatase SYP; SH2 domain-containing protein tyrosine phosphatase-2; Syp; Shp2; PTP1D; PTP2C; SAP-2; SHP-2; SH-PTP2; SH-PTP3; AW536184; 2700084A17Rik |
Gene ID : | 19247 |
mRNA Refseq : | NM_011202 |
Protein Refseq : | NP_035332 |
UniProt ID : | P35235 |
Products Types
◆ Recombinant Protein | ||
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Ptpn11-8674M | Active Recombinant Mouse Ptpn11 protein(Met1-Arg593), His-tagged | +Inquiry |
PTPN11-3522R | Recombinant Rhesus Macaque PTPN11 Protein, His (Fc)-Avi-tagged | +Inquiry |
PTPN11-4489R | Recombinant Rat PTPN11 Protein, His (Fc)-Avi-tagged | +Inquiry |
PTPN11-04H | Active Recombinant Human PTPN11 Protein(Full length), N-GST-tagged | +Inquiry |
◆ Lysates | ||
PTPN11-1334MCL | Recombinant Mouse PTPN11 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, genetic testing can identify mutations in the PTPN11 gene, providing valuable information for diagnosis and treatment planning.
PTPN11 is involved in various signaling pathways, including the RAS-MAPK pathway, and its mutations can dysregulate these pathways, leading to abnormal cell signaling.
Yes, PTPN11 plays a crucial role in normal cellular functions by regulating the activity of proteins through dephosphorylation.
Yes, the presence of PTPN11 mutations can serve as a biomarker for specific cancers and developmental disorders.
Mutations in PTPN11 can lead to developmental disorders, including Noonan syndrome and LEOPARD syndrome, affecting growth and development.
Customer Reviews (3)
Write a reviewTheir technical expertise and knowledge of the PTPN11 protein are invaluable resources.
This reliability reduces experimental variability and enhances the accuracy of data interpretation.
the manufacturer's commitment to continuous innovation and development of new tools and technologies ensures that I have access to the latest advancements in PTPN11 protein research.
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