Cat. No. : |
Rtn4r-4009M |
Description : |
Reticulon 4 receptor (RTN4R), also known as Nogo-66 Receptor (NgR), is a glycosylphosphoinositol (GPI)-anchored protein that belongs to the Nogo recptor family including three members. Mouse RTN4R cDNA contains 10 LRP (Leucine-rich) repeats. RTN4R is expressed predominantly in neurons and their axons in the central nervous systems (CNS). As a receptor for myelin-derived proteins Nogo, myelin-associated glycoprotein (MAG), and myelin oligodendrocyte glycoprotein (OMG), RTN4R mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult CNS. It has been shown that RTN4R performs its inhibitory actions by interacting with the p75 neurotrophin receptor (p75NTR), a TNFRSF member also known for modulating the activities of the Trk family and for inducing apoptosis in neurons and oligodendrocytes. RTN4R may be proposed as a potential drug target for treatment of various neurological conditions such as spinal cord injury, CNS lesions, peripheral nerve injury, stroke and Alzheimer"s disease (AD). Additionally, RTN4R may play a role in regulating the function of the gap junctions. |
Source : |
Mouse |
Host : |
Human Cells |
Form : |
Lyophilized from sterile PBS, pH7.4 |
Purity : |
> 85 % as determined by SDS-PAGE. |
Endotoxin : |
< 1.0 EU per 1μg of the protein as determined by the LAL method. |
Stability : |
Samples are stable for up to twelve months from date of receipt at -70μ |
Predicted N terminal : |
Cys 27 |
Molecular Mass : |
The recombinant mouse RTN4R/Fc chimera is a disulfide-linked homodimer. The reduced monomer consists of 669 amino acids and has a predicted molecular mass of 73.8 kDa. Due to glycosylation, rmRTN4R/Fc monomer migrates as an approximately 95-100 kDa band in SDS-PAGE under reducing conditions. |
Storage : |
Store it under sterile conditions at -70μ upon receiving. Recommend to aliquot the protein into smaller quantities for optimal storage. Avoid repeated freeze-thaw cycles. |