Recombinant Mouse Sdcbp Protein, Myc/DDK-tagged
Cat.No. : | Sdcbp-5728M |
Product Overview : | Purified recombinant protein of mouse full-length syndecan binding protein (Sdcbp), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
- Specification
- Gene Information
- Related Products
Description : | Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis. Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1. In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis. Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 32.4 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Sdcbp syndecan binding protein [ Mus musculus (house mouse) ] |
Official Symbol : | Sdcbp |
Synonyms : | SDCBP; syndecan binding protein; syntenin-1; syntenin; scaffold protein Pbp1; syndecan-binding protein 1; syndecan interacting protein; Sycl; MDA-9 |
Gene ID : | 53378 |
mRNA Refseq : | NM_001098227 |
Protein Refseq : | NP_001091697 |
UniProt ID : | O08992 |
Products Types
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SDCBP-619H | Recombinant Human SDCBP Protein (Met1-Val298), His-tagged | +Inquiry |
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◆ Lysates | ||
SDCBP-2015HCL | Recombinant Human SDCBP 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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