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Recombinant Mouse Sirt1 Protein, Myc/DDK-tagged

Cat.No. : Sirt1-5883M
Product Overview : Purified recombinant protein of mouse full-length sirtuin 1 (Sirt1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
  • Specification
  • Gene Information
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Description : This gene encodes a member of the sirtuin family of proteins, characterized by their deacetylase activity and proposed role in longevity. The encoded protein regulates gene expression in a wide range of cell and tissue types through its NAD+-dependent deacetylation of histones, transcription factors and transcriptional coactivators. Brain-specific overexpression of this gene has been shown to result in increased median lifespan. Viability of homozygous knockout mice for this gene varies with strain background. Homozygous knockout mice of strains that do not exhibit embryonic lethality are sterile and have a reduced lifespan. Alternative splicing results in multiple transcript variants.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 80.8 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Sirt1 sirtuin 1 [ Mus musculus (house mouse) ]
Official Symbol : Sirt1
Synonyms : Sirt1; sirtuin 1; S; Si; Sir2; Sir2a; SIR2L1; AA673258; Sir2alpha; NAD-dependent protein deacetylase sirtuin-1; NAD-dependent protein deacylase sirtuin-1; SIR2-like protein 1; regulatory protein SIR2 homolog 1; sirtuin 1 ((silent mating type information regulation 2, homolog) 1; EC 2.3.1.286
Gene ID : 93759
mRNA Refseq : NM_019812
Protein Refseq : NP_062786
UniProt ID : Q923E4

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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