Recombinant Mouse Smarcc1 Protein, Myc/DDK-tagged

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Recombinant Mouse Smarcc1 Protein, Myc/DDK-tagged

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Cat.No. : Smarcc1-5961M
Product Overview : Purified recombinant protein of mouse full-length SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 (cDNA clone, with C-terminal MYC/DDK tag, expressed in HEK293T cells.
Description : Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. May stimulate the ATPase activity of the catalytic subunit of the complex. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 120 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Smarcc1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 [ Mus musculus (house mouse) ]
Official Symbol : Smarcc1
Synonyms : Smarcc1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1; SR; ms; Rsc8; SRG3; msp3; BAF15; BAF155; AI115498; SWI/SNF complex subunit SMARCC1; BRG1-associated factor 155; SWI/SNF complex 155 kDa subunit; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1; SWI3-related protein
Gene ID : 20588
mRNA Refseq : NM_009211
Protein Refseq : NP_033237
UniProt ID : P97496
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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