Recombinant Mouse Tank Protein, Myc/DDK-tagged
Cat.No. : | Tank-6289M |
Product Overview : | Purified recombinant protein of mouse full-length TRAF family member-associated Nf-kappa B activator (Tank), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
- Specification
- Gene Information
- Related Products
Description : | Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage. Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage. Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage. May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. Essential for the efficient induction of IRF-dependent transcription following infection with Sendai virus. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 47.1 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Tank TRAF family member-associated Nf-kappa B activator [ Mus musculus (house mouse) ] |
Official Symbol : | Tank |
Synonyms : | TANK; TRAF family member-associated Nf-kappa B activator; TRAF family member-associated NF-kappa-B activator; TRAF-interacting protein; C86182; I-TRAF; E430026L09Rik |
Gene ID : | 21353 |
mRNA Refseq : | NM_001164072 |
Protein Refseq : | NP_001157544 |
UniProt ID : | P70347 |
Products Types
◆ Recombinant Protein | ||
TANK-1531H | Recombinant Human TANK Protein (1-119 aa), His-tagged | +Inquiry |
TANK-4431R | Recombinant Rhesus Macaque TANK Protein, His (Fc)-Avi-tagged | +Inquiry |
TANK-4496Z | Recombinant Zebrafish TANK | +Inquiry |
TANK-517H | Recombinant Human TANK | +Inquiry |
TANK-7244H | Recombinant Human TANK, His-tagged | +Inquiry |
◆ Lysates | ||
TANK-1256HCL | Recombinant Human TANK 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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