Recombinant Mouse Tiam2 Protein, Myc/DDK-tagged

• Cat.No.: Tiam2-6425M
• Product Overview: Purified recombinant protein of mouse full-length T cell lymphoma invasion and metastasis 2 (Tiam2), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates specifically RAC1, but not CDC42 and RHOA. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 192.6 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Tiam2 T cell lymphoma invasion and metastasis 2 [ Mus musculus (house mouse) ]
• Official Symbol: Tiam2
• Synonyms: TIAM2; T cell lymphoma invasion and metastasis 2; T-lymphoma invasion and metastasis-inducing protein 2; TIAM-2; SIF and TIAM1-like exchange factor; T-cell lymphoma invasion and metastasis 2; RAS-related C3 botulinum substrate 1, guanine nucleotide exchange factor 1; STEF; mKIAA2016; 3000002F19Rik
• Gene ID: 24001
• mRNA Refseq: NM_011878
• Protein Refseq: NP_036008
• UniProt ID: Q6ZPF3