Recombinant Mouse Tsc22d3 Protein, Myc/DDK-tagged Tsc22d3-6680M

Recombinant Mouse Tsc22d3 Protein, Myc/DDK-tagged


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Cat.No. : Tsc22d3-6680M Optional Service: Optional requirements on this protein
Product Overview : Purified recombinant protein of mouse full-length TSC22 domain family, member 3 (Tsc22d3), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
Description : Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities. Isoform 1 and isoform 4 inhibit myogenic differentiation and mediate anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 15.2 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Tsc22d3 TSC22 domain family, member 3 [ Mus musculus (house mouse) ]
Official Symbol : Tsc22d3
Synonyms : TSC22D3; TSC22 domain family, member 3; TSC22 domain family protein 3; TSC22 domain family 3; TSC22-related inducible leucine zipper 3; TSC22-related-inducible leucine zipper 3; delta sleep inducing peptide, immunoreactor; glucocorticoid-induced leucine zipper protein; long glucocorticoid-induced leucine zipper protein; DIP; Gilz; Dsip1; Tilz3; TSC-22R
Gene ID : 14605
mRNA Refseq : NM_010286
Protein Refseq : NP_034416
UniProt ID : Q9Z2S7
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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