Recombinant Mouse Ubash3a Protein, Myc/DDK-tagged

• Cat.No.: Ubash3a-6776M
• Product Overview: Purified recombinant protein of mouse full-length ubiquitin associated and SH3 domain containing, A (Ubash3a), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 70.1 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Ubash3a ubiquitin associated and SH3 domain containing, A [ Mus musculus (house mouse) ]
• Official Symbol: Ubash3a
• Synonyms: UBASH3A; ubiquitin associated and SH3 domain containing, A; ubiquitin-associated and SH3 domain-containing protein A; T-cell ubiquitin ligand 1; suppressor of T-cell receptor signaling 2; TULA; Sts-2; TULA-1; C330001M22; 5830413C03Rik
• Gene ID: 328795
• mRNA Refseq: NM_177823
• Protein Refseq: NP_808491
• UniProt ID: Q3V3E1