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Recombinant Mouse Usp2 Protein, Myc/DDK-tagged

Cat.No. : Usp2-6868M
Product Overview : Purified recombinant protein of mouse full-length ubiquitin specific peptidase 2 (Usp2), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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Description : Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 2 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells. Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues. Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability. Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 70 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Usp2 ubiquitin specific peptidase 2 [ Mus musculus (house mouse) ]
Official Symbol : Usp2
Synonyms : Usp2; ubiquitin specific peptidase 2; ubp4; Ubp41; B930035K21Rik; ubiquitin carboxyl-terminal hydrolase 2; 41 kDa ubiquitin-specific protease; deubiquitinating enzyme 2; ubiquitin specific protease 2; ubiquitin thioesterase 2; ubiquitin thiolesterase 2; ubiquitin-specific-processing protease 2; EC 3.4.19.12
Gene ID : 53376
mRNA Refseq : NM_016808
Protein Refseq : NP_058088
UniProt ID : O88623

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can USP2 serve as a biomarker for certain diseases? 03/17/2022

It's possible. Elevated levels of USP2 have been associated with certain cancers and metabolic disorders, suggesting its potential as a biomarker for disease diagnosis and prognosis.

Are there any ongoing clinical trials targeting USP2 for diabetes treatment? 09/02/2021

There's research interest in exploring USP2 inhibitors to potentially improve insulin sensitivity and manage diabetes, but clinical trials in this area are still in early stages.

Are there any clinical studies exploring the use of USP2 inhibitors in cancer treatment? 09/01/2020

Yes, several studies are investigating USP2 inhibitors as potential therapeutic agents in cancer treatment to target specific pathways involved in tumor growth.

How does USP2 impact insulin sensitivity and diabetes? 05/27/2020

USP2 has been shown to regulate insulin signaling by deubiquitinating proteins involved in insulin receptor signaling pathways. Dysregulation of USP2 may contribute to insulin resistance in diabetes.

Can USP2 be a potential therapeutic target for drug development? 02/23/2018

Yes, due to its role in regulating protein stability, USP2 is being considered as a potential therapeutic target for drug development, especially in cancer and other diseases involving dysregulated protein turnover.

Customer Reviews (3)

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Reviews
09/14/2022

    Its versatility and reliability make it a great asset in the pursuit of scientific discoveries.

    03/09/2016

      With the USP2 protein, researchers can confidently delve into the complexity of protein structures and gain deeper insights into their functions.

      02/03/2016

        The USP2 protein's exceptional quality and purity guarantee its suitability for a wide range of experimental applications.

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