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Recombinant Rat ARL3 Protein

Cat.No. : ARL3-782R
Product Overview : Recombinant Rat ARL3 full length or partial length protein was expressed.
  • Specification
  • Gene Information
  • Related Products
Source : Mammalian Cells
Species : Rat
Tag : His
Form : Liquid or lyophilized powder
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method.
Purity : >80%
Notes : This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Storage : Store it at +4 ºC for short term. For long term storage, store it at -20 ºC~-80 ºC.
Storage Buffer : PBS buffer
Gene Name : Arl3 ADP-ribosylation factor-like 3 [ Rattus norvegicus ]
Official Symbol : ARL3
Gene ID : 64664
mRNA Refseq : NM_022700.2
Protein Refseq : NP_073191.1
MIM :
UniProt ID : P37996

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (19)

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Can the ARL3 protein be targeted for therapeutic interventions? 09/04/2022

Targeting the ARL3 protein holds potential for therapeutic interventions, particularly in diseases associated with dysfunctional cilia. Modulating the activity or expression of ARL3 may help restore proper ciliary function and alleviate associated symptoms. However, more research is needed to fully understand the implications and feasibility of targeting ARL3 for therapeutic purposes.

Can the ARL3 protein serve as a biomarker for any diseases? 12/17/2021

The potential use of ARL3 as a biomarker is still being explored. While there is limited evidence at present, further research is needed to determine if altered levels or modifications of ARL3 could serve as diagnostic or prognostic markers for specific diseases.

Does the ARL3 protein have any known binding partners? 07/22/2021

Yes, the ARL3 protein interacts with several binding partners. One of its known binding partners is UNC119, a protein involved in the trafficking of lipidated proteins to the ciliary membrane. ARL13B, another protein associated with ciliary function, has been shown to interact with ARL3 as well. These interactions are important for the proper functioning of the cilium.

Are there any post-translational modifications known to occur on the ARL3 protein? 05/24/2021

Yes, the ARL3 protein can undergo post-translational modifications, including lipid modification by geranylgeranylation, which helps in its membrane association. Additional modifications, such as phosphorylation, may also occur and could potentially influence its function.

Is the ARL3 protein implicated in any human diseases? 01/31/2021

Yes, mutations in the ARL3 gene have been associated with Bardet-Biedl syndrome, as mentioned earlier. Additionally, dysregulated ARL3 expression or function has been observed in certain types of cancer, suggesting its potential role in tumorigenesis.

Are there any animal models or knockout studies available for studying ARL3? 01/11/2021

Yes, animal models and knockout studies have been conducted to investigate the function of ARL3. These studies have provided important insights into the role of ARL3 in ciliary biology and related disorders.

Is the ARL3 protein localized to any specific cellular compartments? 10/16/2020

Yes, the ARL3 protein is primarily localized to the membrane of the cilium, a specialized compartment of the cell. It is also found in other membrane-associated compartments such as the Golgi apparatus and endosomes, where it participates in intracellular trafficking processes.

Are there any known functional homologs of the ARL3 protein? 01/14/2020

Yes, other members of the ADP-ribosylation factor-like (ARL) protein family share functional similarities with ARL3. ARL1 and ARL2, for example, are involved in vesicular transport and membrane dynamics, similar to ARL3. These functional homologs may have overlapping roles or act in distinct pathways.

How is the ARL3 protein regulated in cells? 12/29/2019

The regulation of the ARL3 protein is complex and involves various mechanisms. One form of regulation is through post-translational modifications, such as lipid modification and phosphorylation, which can impact ARL3's localization and interactions with other proteins. Other regulatory mechanisms may involve specific protein-protein interactions or signaling pathways that modulate ARL3's activity. Further research is ongoing to elucidate the precise regulatory mechanisms governing ARL3.

How is the ARL3 protein involved in cilium formation? 11/23/2019

The ARL3 protein is crucial for cilium formation and maintenance. It helps in the trafficking and assembly of proteins to the cilium, ensuring the proper composition and structure of this cellular organelle. ARL3 participates in the transport of cargo from the Golgi apparatus to the base of the cilium, facilitating the growth and elongation of the cilium.

Which cellular pathways or processes is the ARL3 protein associated with? 09/03/2019

The ARL3 protein is primarily associated with the ciliary pathway, as it plays a crucial role in maintaining the structure and function of cilia. It is also involved in intracellular trafficking processes, such as vesicle transport and protein sorting.

Can dysregulation of ARL3 expression lead to any cellular defects? 07/25/2019

Yes, dysregulation of ARL3 expression can lead to various cellular defects. Decreased expression of ARL3 has been associated with impaired ciliary trafficking and defects in cilia assembly, affecting cilium structure and function. Dysregulation of ARL3 expression has also been implicated in cellular processes such as cell division and membrane trafficking.

Is the ARL3 protein conserved across different species? 06/26/2018

Yes, the ARL3 protein is highly conserved across various species, indicating its essential role in cellular processes. It shares a significant degree of similarity among vertebrates and exhibits conservation even in lower organisms such as yeast, suggesting its fundamental nature in cellular function.

Is the expression of the ARL3 gene regulated under specific conditions or stimuli? 02/11/2018

The regulation of ARL3 gene expression is not extensively studied. However, some research suggests that its expression can be influenced by certain signaling pathways, such as the Hedgehog signaling pathway, which plays a role in ciliogenesis.

Is there any known genetic variation or mutation in the ARL3 gene? 12/18/2017

Yes, there have been reports of genetic variations and mutations in the ARL3 gene. Certain mutations in ARL3 have been associated with Bardet-Biedl syndrome, a genetic disorder characterized by various symptoms including retinal degeneration and obesity.

Can mutations in the ARL3 gene lead to any human diseases? 12/01/2017

Yes, mutations in the ARL3 gene have been associated with several human diseases. For example, mutations in ARL3 have been linked to Joubert syndrome, a rare genetic disorder characterized by neurological abnormalities and impaired development of the cerebellum and brainstem. Additionally, ARL3 mutations have been implicated in Bardet-Biedl syndrome, a genetic disorder that affects multiple organs and is characterized by obesity, vision loss, and kidney abnormalities.

Has the ARL3 protein been studied in relation to any signaling pathways? 03/28/2017

Yes, the ARL3 protein has been implicated in various signaling pathways. For example, it has been shown to be involved in regulating Hedgehog signaling, a crucial pathway for embryonic development and cell differentiation. ARL3 interacts with proteins in the Hedgehog pathway, affecting its activity.

Are there any known binding partners of the ARL3 protein? 08/20/2016

Yes, the ARL3 protein interacts with various binding partners. Notably, ARL3 is known to interact with ARL13B, a protein involved in ciliogenesis. It also interacts with other proteins that are part of the ciliary machinery.

Are there any known inhibitors or activators of the ARL3 protein? 04/13/2016

Currently, there are no widely known specific inhibitors or activators of the ARL3 protein. However, studies are ongoing to identify potential modulators of its activity, as targeting ARL3 may hold therapeutic potential for certain diseases associated with malfunctioning cilia.

Customer Reviews (8)

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Reviews
01/21/2023

    Its reliable and accurate performance ensures dependable results, contributing to the advancement of scientific knowledge in various fields of study.

    02/12/2022

      The manufacturer's commitment to providing exceptional technical support ensures that I will receive valuable assistance when facing challenges in my research.

      08/21/2020

        Their knowledgeable team is readily available to address any concerns or difficulties I may encounter during my experiments. With their expertise, I can confidently overcome any obstacles and achieve optimal results.

        07/04/2019

          the ARL3 protein offers superior quality and reliability, making it a perfect fit for my experimental needs.

          04/25/2019

            The ARL3 protein comes highly recommended for its excellent performance in various research applications.

            07/04/2017

              Its versatility allows for its effective utilization in a broad range of studies, including molecular biology, cellular assays, and protein interactions analysis.

              06/30/2017

                Their knowledgeable and responsive team assists in troubleshooting and finding solutions to any experimental challenges that may arise.

                10/19/2016

                  The reliable performance of the ARL3 protein in ELISA and its compatibility with protein electron microscopy structure analysis make it an excellent choice for a wide range of research studies.

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