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Recombinant Rat KNG1 Protein (390-639 aa), His-tagged

Cat.No. : KNG1-1435R
Product Overview : Recombinant Rat KNG1 Protein (390-639 aa) is produced by Yeast expression system. This protein is fused with a 6xHis tag at the N-terminal. Protein Description: Partial.
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Description : 1 Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.
Source : Yeast
Species : Rat
Tag : His
Form : Tris-based buffer,50% glycerol
Molecular Mass : 29.8 kDa
Protein length : 390-639 aa
AA Sequence : APRVKKPKESTTVSPSYIARVQEER DPGNEQGPIHGHGWLHAKQIKNKNH QGHKHGHGIGHGHQKPHGLGHGHQL KLDDLKQQREDGYDHRHPVGHGHGQ RHGHGHGHGHGRDKHTNKDKNNVKH TDQRRAPLTSSSEDNTTSTQIQGRT EGFTLNPPLAQPAVISRGFQDSGFT EGVIATTSPYDTETHDDLIPDIHVQ PDSLSFKLISDFPEATSHKCPGRPW KPVSRKDPTIETTEFSDFDLLDALS
Purity : > 90% as determined by SDS-PAGE.
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
Concentration : A hardcopy of COA with reconstitution instruction is sent along with the products.
Gene Name : Kng1 kininogen 1 [ Rattus norvegicus ]
Official Symbol : KNG1
Synonyms : KNG1; kininogen 1; Kng; Tkg; Kngk; Kngt; Map1; TKG6; KINKG; KINKH; Kngt1; KINT1G; Kng_v1; Kng1_v1; MGC93589;
Gene ID : 24903
mRNA Refseq : NM_012696
Protein Refseq : NP_036828
UniProt ID : P08934

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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07/26/2021

    Utilizing protein reagents reduces material consumption in experiments, resulting in resource conservation.

    05/09/2019

      The usage method of protein reagents is flexible, adapting to various experimental requirements.

      01/06/2018

        The precise and reliable results achieved by employing protein reagents make them highly favored in scientific research.

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