Recombinant Rat MAPT Protein (2-752 aa), His-tagged

• Cat.No.: MAPT-647R
• Product Overview: Recombinant Rat MAPT Protein (2-752 aa) is produced by E. coli expression system. This protein is fused with a 6xHis tag at the N-terminal. Protein Description: Full Length of Mature Protein.

Specification

• Description: Promotes microtubule assbly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma mbrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
• Source: E. coli
• Species: Rat
• Tag: His
• Form: Tris-based buffer, 50% glycerol
• Molecular Mass: 82.4 kDa
• Protein length: 2-752 aa
• AA Sequence: AEPRQEFDTMEDQAGDYTMLQDQEG DMDHGLKESPPQPPADDGSEEPGSE TSDAKSTPTAEDVTAPLVEERAPDK QATAQSHTEIPEGTTAEEAGIGDTP NMEDQAAGHVTQEPQKVEIFSQSLL VEPGRREGQAPDSGISDWTHQQVPS MSGAPLPPQGLREATHQPLGTRPED VERSHPASELLWQESPQKEAWGKDR LGSEEEVDEDITMDESSQESPPSQA SLAPGTATPQARSVSASGVSGETTS IPGFPAEGSIPLPADFFSKVSAETQ ASPPEGPGTGPSEEGHEAAPEFTFH VEIKASAPKEQDLEGATVVGAPAEE QKARGPSVGKGTKEASLLEPTDKQP AAGLPGRPVSRVPQLKARVAGVSKD RTGNDEKKAKTSTPSCAKTPSNRPC LSPTRPTPGSSDPLIKPSSPAVCPE PATSPKYVSSVTPRNGSPGTKQMKL KGADGKTGAKIATPRGAATPGQKGT SNATRIPAKTTPSPKTPPGSGEPPK SGERSGYSSPGSPGTPGSRSRTPSL PTPPTREPKKVAVVRTPPKSPSASK SRLQTAPVPMPDLKNVRSKIGSTEN LKHQPGGGKVQIINKKLDLSNVQSK CGSKDNIKHVPGGGSVHIVYKPVDL SKVTSKCGSLGNIHHKPGGGQVEVK SEKLDFKDRVQSKIGSLDNITHVPG GGNKKIETHKLTFRENAKAKTDHGA EIVYKSPVVSGDTSPRHLSNVSSTG SIDMVDSPQLATLADEVSASLAKQG L
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA with concentration instruction is sent along with the products.

Gene Information

• Gene Name: Mapt microtubule-associated protein tau [ Rattus norvegicus ]
• Official Symbol: MAPT
• Synonyms: MAPT; PHF-tau; pTau; Mtapt; RNPTAU; MGC156663
• Gene ID: 29477
• mRNA Refseq: NM_017212
• Protein Refseq: NP_058908
• UniProt ID: P19332